Hofmann H, Schmut O, Sterk H, Kopp H
Z Naturforsch C Biosci. 1979 Aug;34(7-8):508-11.
Reductions with [3H5NaBH4 proof that the decrease in viscosity of hyaluronic acid solutions caused by lowering the pH does not depend on a depolymerisation of hyaluronic acid. At the same time investigations at different pH-values, show a sigmoide increase of the Spin-Lattice-Relaxationtime T1. This increase depends on a progressive aggregation of the hyaluronic acid molecule. The effect seems to be induced by the decrease of ionization of the carboxylgroups, by acidification of the solution.
用[3H5NaBH4]还原证明，降低pH值导致透明质酸溶液粘度降低并不取决于透明质酸的解聚。同时，在不同pH值下的研究表明，自旋晶格弛豫时间T1呈S形增加。这种增加取决于透明质酸分子的逐步聚集。这种效应似乎是由溶液酸化导致羧基电离减少所引起的。
