用于联烯基手性的轴手性含磷联烯的对映选择性合成。
Enantioselective synthesis of axially chiral P-containing allenes for allenyl chirality.
作者信息
Feng Guangshou, Wang Qiu
机构信息
Department of Chemistry, Duke University, Durham, North Carolina 27708, United States.
出版信息
Chem Catal. 2024 Mar 21;4(3). doi: 10.1016/j.checat.2024.100954.
Abstract
In this issue of Chem Catalysis, Wang J. and co-workers have established an efficient and practical route to construct versatile di-, tri-, and tetra-substituted phosphoryl allenes via a nickel-catalyzed propargylic substitution reaction, offering a powerful tool for the assembly of axially chiral phosphorus-containing allenes.
摘要
在本期《化学催化》中，王J.及其同事通过镍催化的炔丙基取代反应，建立了一条高效且实用的路线来构建通用的二取代、三取代和四取代磷酰基丙二烯，为轴向手性含磷丙二烯的组装提供了一个强大的工具。
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本文引用的文献
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P-Stereogenic Amino-Phosphines as Chiral Ligands: From Privileged Intermediates to Asymmetric Catalysis.手性膦-氨基酸配体作为手性配体：从优势中间体到不对称催化。
Acc Chem Res. 2020 Mar 17;53(3):676-689. doi: 10.1021/acs.accounts.9b00633. Epub 2020 Feb 27.
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Structure-activity relationship of (N)-Methanocarba phosphonate analogues of 5'-AMP as cardioprotective agents acting through a cardiac P2X receptor.（N）-甲撑膦酸酯类似物作为通过心脏 P2X 受体发挥作用的心脏保护剂的 5'-AMP 的构效关系。
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Allenes in asymmetric catalysis: asymmetric ring opening of meso-epoxides catalyzed by allene-containing phosphine oxides.联烯在不对称催化中的应用：含联烯的氧化膦催化内消旋环氧化合物的不对称开环反应
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