Liu Chenguang, Luo Yawen, Zhou Huan, Lin Meixi, Zang Dan, Chen Jun
Department of Oncology, the Second Hospital of Dalian Medical University, Dalian 116023, China.
Chin J Cancer Res. 2025 Apr 30;37(2):250-267. doi: 10.21147/j.issn.1000-9604.2025.02.10.
The intricate interactions between immune cells and tumors exert a profound influence on cancer progression and therapeutic efficacy. Within the tumor microenvironment, exosomes have emerged as pivotal mediators of intercellular communication, with their cargo of non-coding RNAs (ncRNAs) serving as key regulatory elements. This review examines the multifaceted roles of immune cell-derived exosomal ncRNAs in tumor biology. The involvement of various immune cells, including T cells, B cells, natural killer cells, macrophages, neutrophils, and myeloid-derived suppressor cells, in utilizing exosomal ncRNAs to regulate tumor initiation and progression is explored. Additionally, the biogenesis and delivery mechanisms of these immune cell-derived exosomal ncRNAs are discussed, alongside their potential clinical applications in cancer.
免疫细胞与肿瘤之间复杂的相互作用对癌症进展和治疗效果产生深远影响。在肿瘤微环境中，外泌体已成为细胞间通讯的关键介质，其携带的非编码RNA（ncRNAs）作为关键调节元件。本综述探讨了免疫细胞衍生的外泌体ncRNAs在肿瘤生物学中的多方面作用。研究了包括T细胞、B细胞、自然杀伤细胞、巨噬细胞、中性粒细胞和髓源性抑制细胞在内的各种免疫细胞如何利用外泌体ncRNAs来调节肿瘤的发生和进展。此外，还讨论了这些免疫细胞衍生的外泌体ncRNAs的生物发生和传递机制，以及它们在癌症中的潜在临床应用。
