College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
College of First Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Cancer Lett. 2023 Jan 1;552:215975. doi: 10.1016/j.canlet.2022.215975. Epub 2022 Oct 25.
As a biological carrier, exosomes participate in the communication between various kinds of cells, and can mediate the interactive 'dialogue' between tumor cells and tumor-associated macrophages (TAMs). TAMs are the most abundant cell population in the tumor stroma and are an important part of the tumor immune microenvironment. Various stimulating factors in the tumor microenvironment influence the polarization of TAMs into multiple phenotypes, such as M1 and M2. It plays a dual role in tumor immunity by both promoting and inhibiting tumor growth. Exosome-encapsulated non-coding RNAs (ncRNAs) participate in the interactive 'dialogue' between exosome-mediated TAMs and tumor cells. Tumor-derived exosomal ncRNAs can promote macrophage polarization, whereas exosomal ncRNAs derived from TAMs can affect tumor proliferation, metastasis, angiogenesis, and chemotherapy resistance. The present review summarizes the dual effects of exosomal ncRNAs on tumor cells and TAMs, and discusses the application of exosomal ncRNAs as a potential diagnostic or prognostic marker and drug delivery system, to provide a new perspective and potential therapeutic drugs on targeting exosomes and macrophages in the treatment of tumors.
作为一种生物载体，外泌体参与各种细胞之间的通讯，能够介导肿瘤细胞与肿瘤相关巨噬细胞（TAMs）之间的相互“对话”。TAMs 是肿瘤基质中最丰富的细胞群体，是肿瘤免疫微环境的重要组成部分。肿瘤微环境中的各种刺激因子影响 TAMs 向多个表型（如 M1 和 M2）的极化。它通过促进和抑制肿瘤生长在肿瘤免疫中发挥双重作用。外泌体包裹的非编码 RNA（ncRNA）参与外泌体介导的 TAMs 与肿瘤细胞之间的相互“对话”。肿瘤来源的外泌体 ncRNA 可以促进巨噬细胞极化，而来自 TAMs 的外泌体 ncRNA 可以影响肿瘤的增殖、转移、血管生成和化疗耐药性。本综述总结了外泌体 ncRNA 对肿瘤细胞和 TAMs 的双重作用，并讨论了将外泌体 ncRNA 作为一种有潜力的诊断或预后标志物和药物递送系统的应用，为靶向外泌体和巨噬细胞治疗肿瘤提供了新的视角和潜在的治疗药物。
