Environmental Pollution and Reproductive Health: The Cause for Concern.

Currently, there is a growing concern for human health with the rise of environmental pollution. Water contamination and health problems had been understood. Sanitation-related health issues have been overcome in the greater part of the world. Progressive industrialization has caused a number of new pollutants in water and in the atmosphere. It is a growing concern for the human health, especially upon the reproductive health. Current researchers provide a strong association between the rising concentrations of ambient pollutants and the adverse health impact. Furthermore, the pollutants have the adverse effects upon reproductive health as well. Major concern is for the health of a pregnant woman and her baby. Maternal-fetal inflammatory response due to the pollutants affects the pregnancy outcome adversely. Preterm labor, fetal growth restriction, intrauterine fetal death, and stillbirths have been observed. Varieties of pathological processes including inflammation, endocrine dysfunction, epigenetic changes, oxidative and nitrosative stress, and placental dysfunction have been explained as the biological plausibility. Prospective studies (systematic review and meta-analysis) have established that exposure to particulate matters (PM) and the nanoparticles (NP) leads to excessive oxidative changes to cause DNA mutations, lipid peroxidation and protein oxidation. Progressive industrialization and emergence of heavy metals, micro- (MP) and nanoparticles (NP) in the atmosphere and in water are the cause for concern. However, most of the information is based on studies from industrialized countries. India needs its own country-based study to have the exact idea and to develop the mechanistic pathways for the control.