定义动物细胞中的脂质转运途径。
Defining lipid transport pathways in animal cells.
作者信息
Pagano R E, Sleight R G
出版信息
Science. 1985 Sep 13;229(4718):1051-7. doi: 10.1126/science.4035344.
PMID:4035344
Abstract
A new technique for studying the metabolism and intracellular transport of lipid molecules in living cells based on the use of fluorescent lipid analogs is described. The cellular processing of various intermediates (phosphatidic acid and ceramide) and end products (phosphatidylcholine and phosphatidylethanolamine) in lipid biosynthesis is reviewed and a working model for compartmentalization during lipid biosynthesis is presented.
摘要
本文描述了一种基于使用荧光脂质类似物来研究活细胞中脂质分子代谢和细胞内运输的新技术。综述了脂质生物合成中各种中间体（磷脂酸和神经酰胺）和终产物（磷脂酰胆碱和磷脂酰乙醇胺）的细胞加工过程，并提出了脂质生物合成过程中分区化的工作模型。
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