Heinz-Erian P, Dey R D, Flux M, Said S I
Science. 1985 Sep 27;229(4720):1407-8. doi: 10.1126/science.4035357.
The innervation of acini and ducts of eccrine sweat glands by immunoreactive, vasoactive intestinal peptide-containing nerve fibers was sharply reduced in seven patients with cystic fibrosis compared to eight normal subjects. The decrease in innervation by this neuropeptide, which has been shown to promote blood flow and the movement of water and chloride across epithelial surfaces in other systems, may be a basic mechanism for the decreased water content and relative impermeability of the epithelium to chloride and other ions that characterize cystic fibrosis.
与8名正常受试者相比，7名囊性纤维化患者中，含有免疫反应性、血管活性肠肽的神经纤维对小汗腺腺泡和导管的神经支配明显减少。这种神经肽已被证明在其他系统中可促进血液流动以及水和氯离子跨上皮表面的移动，其神经支配的减少可能是导致囊性纤维化特征性的上皮含水量降低以及上皮对氯离子和其他离子相对不渗透性的一种基本机制。
