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右旋苯丙胺对鸽子自动维持的按键行为的影响。

The effects of d-amphetamine on the automaintained key pecking of pigeons.

作者信息

Poling A, Thompson T

出版信息

Psychopharmacology (Berl). 1977 Mar 16;51(3):285-8. doi: 10.1007/BF00431637.

Abstract

Three food-deprived pigeons were initially exposed to an automaintenance procedure in which 8-s response key illuminations were followed by food delivery without regard to the subject's behavior. The percentage of occasions on which key illumination was followed by food delivery was then successively reduced from 100 to 50, 25, 10, and 2.5%. Despite the lack of a programmed contingency between key pecking and food delivery or key illumination, key pecking occurred under all automaintenance conditions. Mean responses per 8-s key illumination during non-drug sessions varied from over 15 to less than one, with the 100 and 50% pairing conditions engendering the highest rates and the 2.5% pairing condition the lowest. Under all automaintenance conditions, d-amphetamine in does of 0.5, 1, and 2 mg/kg decreased responding in a dose-dependent fashion. Rate-dependent effects were not evident despite the appreciable differences in mean response rates engendered by the various conditions.

摘要

三只处于食物剥夺状态的鸽子最初接受了一种自动维持程序,在此程序中,8秒的反应键照明后会提供食物,而不考虑实验对象的行为。随后,反应键照明后紧接着提供食物的情况所占百分比依次从100%降至50%、25%、10%和2.5%。尽管在按键啄击与食物递送或反应键照明之间不存在设定的偶然联系,但在所有自动维持条件下都出现了按键啄击行为。在非药物实验阶段,每8秒反应键照明期间的平均反应次数从超过15次到少于1次不等,其中100%和50%配对条件下的反应率最高,2.5%配对条件下的反应率最低。在所有自动维持条件下,0.5、1和2毫克/千克剂量的右旋苯丙胺均以剂量依赖的方式减少反应。尽管不同条件下产生的平均反应率存在明显差异,但速率依赖性效应并不明显。

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