Handley S L, Miskin R C
Psychopharmacology (Berl). 1977 Mar 16;51(3):305-9. doi: 10.1007/BF00431641.
The kynurenine pathway metabolites kynurenine, 3-hydroxykynurenine and xanthurenic acid have been tested against 5-hydroxytryptamine (5-HT) and 5-hydroxytryptophan (5-HTP)-induced head twitches in the mouse in a dose-range of 0.5--5.0 mg/kg. Kynurenine and 3-hydroxykynurenine were highly active. Low doses caused marked potentiation of the twitch response to both 5-HT and 5-HTP with increased toxicity of 5-HT. High doses caused antagonism of both responses. Xanthurenic acid was inactive over the same dose range. The effects of kynurenine could not be duplicated in the guinea-pig ileum. The relevance of these results to the involvement of kynurenine pathway metabolites in depressive illness is discussed.
犬尿氨酸途径的代谢产物犬尿氨酸、3-羟基犬尿氨酸和黄尿酸，在0.5-5.0mg/kg的剂量范围内，针对小鼠体内5-羟色胺（5-HT）和5-羟色氨酸（5-HTP）诱导的头部抽搐进行了测试。犬尿氨酸和3-羟基犬尿氨酸具有高度活性。低剂量时，对5-HT和5-HTP的抽搐反应均有明显增强作用，同时5-HT的毒性增加。高剂量时，两种反应均受到拮抗。黄尿酸在相同剂量范围内无活性。犬尿氨酸对豚鼠回肠的作用无法重现。讨论了这些结果与犬尿氨酸途径代谢产物参与抑郁症的相关性。
