Liu Yufeng, Wang Tricia T, Lu Yinsheng, Riaz Muhammad, Qyang Yibing
Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department, New Haven, CT, USA; Yale Biological and Biomedical Sciences, Graduate School of Arts and Sciences, Yale University, New Haven, CT, USA.
Yale Biological and Biomedical Sciences, Graduate School of Arts and Sciences, Yale University, New Haven, CT, USA.
J Mol Cell Cardiol. 2025 Jul;204:17-31. doi: 10.1016/j.yjmcc.2025.05.001. Epub 2025 May 10.
Macrophages are a cell type that are known to play dynamic roles in acute and progressive pathology. They are highly attuned to their microenvironments throughout maturation, tailoring their functional responses according to the specific tissues in which they reside and their developmental origin. Cardiac macrophages (cMacs) have emerged as focal points of interest for their interactions with the unique electrical and mechanical stimuli of the heart, as well as for their role in maintaining cardiac homeostasis. Through an in-depth analysis of their origin, lineage, and functional significance, this review aims to shed light on cMacs' distinct contributions to both normal physiological maintenance as well as disease progression. Central to our discussion is the comparison of cMac characteristics between mouse and human models, highlighting current challenges and proposing novel experimental tools for deciphering cMac function within the intricate human cardiac microenvironments based on current murine studies. Our review offers valuable insights for identifying novel therapeutic targets and interventions tailored to the distinct roles of these immune cells in cardiovascular diseases (CVDs).
巨噬细胞是一种已知在急性和进行性病理过程中发挥动态作用的细胞类型。在整个成熟过程中，它们对其微环境高度敏感，根据它们所驻留的特定组织及其发育起源来调整其功能反应。心脏巨噬细胞（cMacs）因其与心脏独特的电和机械刺激的相互作用以及在维持心脏内环境稳态中的作用而成为关注焦点。通过对其起源、谱系和功能意义的深入分析，本综述旨在阐明cMacs对正常生理维持以及疾病进展的独特贡献。我们讨论的核心是比较小鼠和人类模型中cMac的特征，强调当前面临的挑战，并根据当前的小鼠研究提出用于在复杂的人类心脏微环境中解读cMac功能的新型实验工具。我们的综述为确定针对这些免疫细胞在心血管疾病（CVDs）中的不同作用的新型治疗靶点和干预措施提供了有价值的见解。
