Beyond beauty: Neurocosmetics, the skin-brain axis, and the future of emotionally intelligent skincare.

The bidirectional communication between the skin and brain has emerged as a promising scientific paradigm in dermatology and cosmetic medicine. Neurocosmetics, a frontier at the intersection of neuroscience, dermatology, and psychodermatology, aims to target this skin-brain axis to enhance not only skin health but also emotional well being. This commentary explores the underlying neurocutaneous and neuroimmune mechanisms, the emerging role of the skin microbiome in emotion-linked skin responses, and how artificial intelligence technologies can help personalize these strategies. The convergence of neuroscience and dermatology may pave the way for a new generation of evidence-based skincare with psychophysiological impact, a transformative concept in clinical and cosmetic practice.