Belachew Tegegne Wale, Mekuriaw Begizew Yimenu, Ferede Wassie Yazie, Tegegne Dagnaw Mersha, Mengistu Temesgen Dessie, Tadesse Selamawit Girma, Tariku Yaregal Dessalew, Sisay Fillorenes Ayalew, Erega Besfat Berihun, Goshu Yitayal Ayalew, Mitiku Assefa Kebie
Midwifery, Debre Tabor University, Debre Tabor, Ethiopia
Debre Tabor University, Debre Tabor, Ethiopia.
BMJ Open. 2025 May 12;15(5):e096713. doi: 10.1136/bmjopen-2024-096713.
The involvement of male partners in the care and treatment of HIV-positive pregnant women is essential for improving health outcomes and ensuring optimal adherence to antiretroviral therapy (ART). Although ART has been shown to be effective in preventing mother-to-child transmission of HIV, maintaining adherence to the prescribed triple ART regimen remains a significant challenge. However, there has been a lack of research on the role of male partners in supporting ART adherence during pregnancy.
To assess male partner involvement in triple ART drug adherence and associated factors among HIV-positive pregnant women in government hospitals of the North Gojjam Zone, Amhara Region, Northwest Ethiopia, 2023.
An institution-based cross-sectional study was conducted.
The study was carried out in hospitals located in the North Gojjam Zone of Northwest Ethiopia.
The study was conducted among 410 male partners of HIV-positive pregnant women from 1 April 2023 to 30 May 2023.
The primary outcome was to assess the involvement of male partners in triple ART adherence, while the secondary outcome was to identify factors associated with the involvement of male partners on triple ART adherence among HIV-positive pregnant women. The association between variables was assessed using bivariate and multivariable logistic regression models, and a p value <0.05 with a 95% CI was considered statistically significant.
A total of 410 participants were included, with a response rate of 97.2%. The prevalence of male partner involvement in triple ART drug adherence among HIV-positive pregnant women was 21.2%. Multivariable logistic regression showed that educational status (AOR (Adjusted Odds Ratio)=2.5, 95% CI 1.26 to 4.96), place of residence (AOR=4.8, 95% CI 3.17 to 7.27), and the time taken to travel from home to the facility (AOR=3.1, 95% CI 1.51 to 6.36) were significantly associated with male partner involvement.
This study demonstrates that compared with a study conducted in Malawi, male partner involvement in triple ART drug adherence was lower. Male partner involvement in triple ART adherence among HIV-positive pregnant women was strongly associated with educational status, place of residence and the time taken to travel from home to the health facility. Empowering men to actively participate in healthcare decisions and treatment plans for their partners can foster a sense of responsibility and enhance commitment to adherence.
男性伴侣参与艾滋病毒阳性孕妇的护理和治疗对于改善健康结果和确保最佳抗逆转录病毒疗法（ART）依从性至关重要。尽管抗逆转录病毒疗法已被证明在预防艾滋病毒母婴传播方面有效，但维持对规定的三联抗逆转录病毒疗法方案的依从性仍然是一项重大挑战。然而，关于男性伴侣在孕期支持抗逆转录病毒疗法依从性方面的作用，一直缺乏研究。
评估2023年埃塞俄比亚西北部阿姆哈拉地区北戈贾姆区政府医院中男性伴侣对艾滋病毒阳性孕妇三联抗逆转录病毒药物依从性的参与情况及相关因素。
进行了一项基于机构的横断面研究。
该研究在埃塞俄比亚西北部北戈贾姆区的医院开展。
2023年4月1日至2023年5月31日期间，对410名艾滋病毒阳性孕妇的男性伴侣进行了研究。
主要结果是评估男性伴侣对三联抗逆转录病毒疗法依从性的参与情况，次要结果是确定与艾滋病毒阳性孕妇中男性伴侣参与三联抗逆转录病毒疗法依从性相关的因素。使用二元和多变量逻辑回归模型评估变量之间的关联，p值<0.05且95%置信区间被认为具有统计学意义。
共纳入410名参与者，应答率为97.2%。艾滋病毒阳性孕妇中男性伴侣参与三联抗逆转录病毒药物依从性的患病率为21.2%。多变量逻辑回归显示，教育程度（调整优势比[AOR]=2.5，95%置信区间1.26至4.96）、居住地点（AOR=4.8，95%置信区间3.17至7.27）以及从家到医疗机构的出行时间（AOR=3.1，95%置信区间1.51至6.36）与男性伴侣的参与显著相关。
本研究表明，与在马拉维进行的一项研究相比，男性伴侣对三联抗逆转录病毒药物依从性的参与程度较低。艾滋病毒阳性孕妇中男性伴侣参与三联抗逆转录病毒疗法依从性与教育程度、居住地点以及从家到医疗机构的出行时间密切相关。使男性有能力积极参与其伴侣的医疗保健决策和治疗计划，可以培养责任感并增强对依从性的承诺。
