Sebastião Cruz S, Machado Michel G, Vigário João, Comandante Felícia, Armando António, Silva Maria L S, Sebastião Joana M K, Manico Eunice, Machado Deodete, Pimentel Victor
Centro Nacional de Investigação Científica (CNIC), Luanda, Angola.
Centro de Investigação em Saúde de Angola (CISA) | Instituto Nacional de Investigação em Saúde (INIS), Luanda, Angola.
Sci Rep. 2025 May 12;15(1):16478. doi: 10.1038/s41598-025-01089-w.
Hepatitis B virus (HBV) infection is a global public health concern with a high burden in the African region. Assessing trends in HBV infection over time can provide insights into the effectiveness of prevention/treatment strategies in different settings. Herein, we investigate trends in active HBV infection and associated risk factors among blood donor candidates from Luanda, Angola. This was a retrospective study conducted with 96,654 medical records of blood donors consulted between 2018 and 2022 at the Angolan National Blood Institute. Participants were screened for hepatitis B surface antigen (HBsAg). Chi-square, Prevalence Ratio, and logistic regression were used to analyse interactions between demographic variables and were deemed significant when p < 0.05. Active HBV infection was 10% (95% CI: 9.4-10.6). Men (AOR: 1.38, p < 0.001), employed (AOR: 3.25, p < 0.001) and non-urbanised regions (AOR: 1.16, p = 0.019), were more likely to contract the HBV, while aged 30 years or older (AOR: 0.78, p < 0.001) and married (AOR: 0.66, p < 0.001), were less likely to contract the infection. From 2018 to 2022, HBV infections increased from 18.2 to 21.9%. Infections increased in under 30 years (31.3-52.5%, p < 0.001), males (91.1 to 91.8%, p = 0.149), urbanised regions (2.7 to 3.3%, p = 0.538), and unmarried (93.9 to 95.8%, p = 0.019). We revealed a highly active HBV infection over the past 5 years in the adult population of Luanda, Angola. Age, gender, occupation, place of residence and marital status have influenced the dissemination of HBV in Angola. Our findings may facilitate the planning and evaluation of the HBV control program in Angola.
乙型肝炎病毒（HBV）感染是一个全球公共卫生问题，在非洲地区负担沉重。评估HBV感染随时间的趋势可以深入了解不同环境下预防/治疗策略的有效性。在此，我们调查了安哥拉罗安达献血候选者中活动性HBV感染的趋势及相关危险因素。这是一项回顾性研究，对2018年至2022年期间在安哥拉国家血液研究所查阅的96654份献血者医疗记录进行了研究。参与者接受了乙型肝炎表面抗原（HBsAg）筛查。采用卡方检验、患病率比和逻辑回归分析人口统计学变量之间的相互作用，当p<0.05时被认为具有统计学意义。活动性HBV感染率为10%（95%CI：9.4-10.6）。男性（调整后比值比[AOR]：1.38，p<0.001）、就业者（AOR：3.25，p<0.001）和非城市化地区（AOR：1.16，p=0.019）感染HBV的可能性更高，而30岁及以上（AOR：0.78，p<0.001）和已婚者（AOR：0.66，p<0.001）感染的可能性较低。从2018年到2022年，HBV感染率从18.2%上升到21.9%。30岁以下人群（31.3%-52.5%，p<0.001）、男性（91.1%至91.8%，p=0.149）、城市化地区（2.7%至3.3%，p=0.538）和未婚者（93.9%至95.8%，p=0.019）的感染率有所上升。我们发现，在过去5年中，安哥拉罗安达的成年人群中HBV感染非常活跃。年龄、性别、职业、居住地点和婚姻状况影响了HBV在安哥拉的传播。我们的研究结果可能有助于安哥拉HBV控制项目的规划和评估。
