Jandondo Domingos, Pimentel Victor, Vigário João, Vienga Pedro, Sebastião Joana M K, Mateus Anabela, Comandante Felícia, Sacomboio Euclides, Abecasis Ana, Manico Eunice, Machado Deodete, David Zinga, de Vasconcelos Jocelyne Neto, Morais Joana, Sebastião Cruz S
Centro de Investigação em Saúde de Angola (CISA) Caxito Angola.
Instituto Nacional de Investigação em Saúde (INIS) Luanda Angola.
Health Sci Rep. 2024 Aug 6;7(8):e2287. doi: 10.1002/hsr2.2287. eCollection 2024 Aug.
Hepatitis B virus (HBV) remains a public health concern. Blood donors screened for HBV surface antigen (HBsAg) along with aspartate transaminase (AST)/alanine aminotransferase (ALT) could play a key in providing safe blood products. We investigated the features related to HBV infection among rejected blood donors in Luanda, Angola.
This was a cross-sectional study conducted with 164 rejected donors. Donors were screened for HBsAg from March to May 2022. Overall, 63.4% tested positive for HBV.
The mean age of the HBV-positive (29.2 ± 8.02) was lower than the HBV-negative (33.9 ± 10.0) ( < 0.001). Donors between 20 and 40 years (odds ratio [OR]: 2.34, = 0.045), females (OR: 1.40, = 0.516), residents in urbanized areas (OR: 1.23, = 0.530), low educational (OR: 1.54, = 0.458), unemployed (OR: 1.65, = 0.271), and unmarried (OR:1.41, = 0.616) might be likely to contract HBV. AST/ALT ratio was higher in HBV-infected (2.07 ± 1.42) than in HBV-uninfected (1.90 ± 1.14). About 20% of HBV-positive were classified as having acute liver disease, while 80% with chronic liver disease, based on AST/ALT ratio. Age ranged from 20 to 40 years (OR: 1.97, = 0.305), females (OR: 1.61, = 0.557), donors from non-urbanized (OR: 1.69, = 0.557), a low educational (OR: 1.64, = 0.571), and unemployed donors (OR: 1.81, = 0.289) were likely to develop chronic liver disease.
Our findings indicated the failure of viral hepatitis control measures. Authorities should consider including HBV nucleic acid testing to ensure early identification of HBV in Angola.
乙型肝炎病毒（HBV）仍然是一个公共卫生问题。对献血者进行HBV表面抗原（HBsAg）以及天冬氨酸转氨酶（AST）/丙氨酸转氨酶（ALT）筛查，对于提供安全的血液制品至关重要。我们调查了安哥拉罗安达被拒绝献血者中与HBV感染相关的特征。
这是一项对164名被拒绝献血者进行的横断面研究。于2022年3月至5月对献血者进行HBsAg筛查。总体而言，63.4%的人HBV检测呈阳性。
HBV阳性者的平均年龄（29.2±8.02）低于HBV阴性者（33.9±10.0）（P<0.001）。20至40岁的献血者（优势比[OR]：2.34，P=0.045）、女性（OR：1.40，P=0.516）、城市化地区居民（OR：1.23，P=0.530）、低学历者（OR：1.54，P=0.458）、失业者（OR：1.65，P=0.271）以及未婚者（OR：1.41，P=0.616）感染HBV的可能性可能更高。HBV感染者的AST/ALT比值（2.07±1.42）高于未感染HBV者（1.90±1.14）。根据AST/ALT比值，约20%的HBV阳性者被归类为患有急性肝病，而80%患有慢性肝病。年龄在20至40岁之间的献血者（OR：1.97，P=0.305）、女性（OR：1.61，P=0.557）、非城市化地区的献血者（OR：1.69，P=0.557）、低学历者（OR：1.64，P=0.571）以及失业献血者（OR：1.81，P=0.289）患慢性肝病的可能性更大。
我们的研究结果表明病毒性肝炎控制措施存在不足。安哥拉当局应考虑纳入HBV核酸检测，以确保早期发现HBV。
