脊髓与腰段脑脊液之间5-羟吲哚乙酸的交换
Exchange of 5-hydroxyindoleacetic acid between the spinal cord and lumbar cerebrospinal fluid.
作者信息
Bulat M, Zivković B
出版信息
J Physiol. 1978 Feb;275:191-7. doi: 10.1113/jphysiol.1978.sp012185.
Abstract
- After inhibition of 5-hydroxyindoleacetic acid (5-HIAA) transport by repeated administration of probenecid in cats, this acid accumulates linearly in the lumbosacral cord, lumbar cerebrospinal fluid (c.s.f.) and cisternal fluid during 5 hr of experiment. 2. A simple mathematical analysis of these results shows that (a) the rates of 5-HIAA accumulation in the lumbar c.s.f. and cisternal c.s.f. are faster than in the cord, (b) about 22% of 5-HIAA formed in the cord diffuses into lumbar c.s.f. and (c) by measuring 5-HIAA in the lumbar c.s.f. the concentration and turnover of 5-HIAA and turnover of serotonin in the lumbosacral cord can be calculated as well as the changes of 5-HIAA in the cisternal c.s.f. predicted. 3. These results suggest that it is possible to calculate the level and turnover of endogenous substances in the central nervous system on the basis of their measurement in the c.s.f.
摘要
- 通过在猫身上反复给予丙磺舒抑制5-羟吲哚乙酸（5-HIAA）转运后，在5小时的实验过程中，这种酸在腰骶脊髓、腰段脑脊液（c.s.f.）和脑池液中呈线性累积。2. 对这些结果进行简单的数学分析表明：（a）5-HIAA在腰段脑脊液和脑池脑脊液中的累积速率比在脊髓中更快；（b）脊髓中形成的5-HIAA约22%扩散到腰段脑脊液中；（c）通过测量腰段脑脊液中的5-HIAA，可以计算腰骶脊髓中5-HIAA的浓度和周转率以及血清素的周转率，还可以预测脑池脑脊液中5-HIAA的变化。3. 这些结果表明，有可能根据脑脊液中内源性物质的测量来计算中枢神经系统中这些物质的水平和周转率。
相似文献
1
Exchange of 5-hydroxyindoleacetic acid between the spinal cord and lumbar cerebrospinal fluid.脊髓与腰段脑脊液之间5-羟吲哚乙酸的交换
J Physiol. 1978 Feb;275:191-7. doi: 10.1113/jphysiol.1978.sp012185.
2
Effect of probenecid on 5-hydroxyindoleacetic acid in cisternal cerebrospinal fluid of rats with portacaval anastomosis.丙磺舒对门腔静脉吻合大鼠脑池脑脊液中5-羟吲哚乙酸的影响。
Neurochem Res. 1995 Aug;20(8):963-7. doi: 10.1007/BF00970743.
3
Evidence for a probenecid-sensitive transport system of acid monoamine metabolites from the spinal subarachnoid space.来自脊髓蛛网膜下腔的酸性单胺代谢产物的丙磺舒敏感转运系统的证据。
Psychopharmacology (Berl). 1977 Mar 23;52(1):35-40. doi: 10.1007/BF00426597.
4
Transport of 5-hydroxy-3-indoleacetic acid by spinal cord during subarachnoid perfusion.
Brain Res. 1976 Nov 12;116(3):471-83. doi: 10.1016/0006-8993(76)90494-7.
5
6
Clearance of amine metabolites from the cerebrospinal fluid: the brain as a "sink".脑脊液中胺类代谢物的清除：作为“汇”的脑
Neurology. 1974 Aug;24(8):772-9. doi: 10.1212/wnl.24.8.772.
7
Inhibition of 5-hydroxyindoleacetic acid transport from the spinal fluid by probenecid.丙磺舒对脊髓液中5-羟吲哚乙酸转运的抑制作用。
J Pharm Pharmacol. 1971 Jul;23(7):539-40. doi: 10.1111/j.2042-7158.1971.tb08705.x.
8
2,4-Dinitrophenol inhibition of transport of 5-hydroxyindoleacetic acid from the cerebrospinal fluid and spinal cord.2,4-二硝基苯酚对5-羟吲哚乙酸从脑脊液和脊髓转运的抑制作用。
J Pharm Pharmacol. 1977 Dec;29(12):773-4. doi: 10.1111/j.2042-7158.1977.tb11462.x.
9
The active transport of 5-hydroxyindol-3-ylacetic acid and 3-methoxy-4-hydroxyphenylacetic acid from a recirculatory perfusion system of the cerebral ventricles of the unanaesthetized dog.未麻醉犬脑室循环灌注系统中5-羟吲哚-3-乙酸和3-甲氧基-4-羟基苯乙酸的主动转运
J Physiol. 1968 Dec;199(2):397-425. doi: 10.1113/jphysiol.1968.sp008660.
10
5-Hydroxyindoleacetic acid in the lumbar fluid: a specific indicator of spinal cord injury.脑脊液中的5-羟吲哚乙酸：脊髓损伤的特异性指标。
Science. 1974 Aug 9;185(4150):527-8. doi: 10.1126/science.185.4150.527.
引用本文的文献
1
Enigma of cerebrospinal fluid dynamics.脑脊液动力学之谜。
Croat Med J. 2014 Aug 28;55(4):287-90. doi: 10.3325/cmj.2014.55.287.
2
On the significance of monoamines and their metabolites in the cerebrospinal fluid of the sheep.单胺及其代谢产物在绵羊脑脊液中的意义
J Physiol. 1984 Mar;348:457-69. doi: 10.1113/jphysiol.1984.sp015119.
本文引用的文献
1
CELLULAR LOCALIZATION OF MONOAMINES IN THE SPINAL CORD.脊髓中单胺类物质的细胞定位
Acta Physiol Scand. 1964 Jan-Feb;60:112-9. doi: 10.1111/j.1748-1716.1964.tb02874.x.
2
Drug-induced changes in the concentration of 5-OR indolyl compounds in cerebrospinal fluid and caudate nucleus.药物引起的脑脊液和尾状核中5-羟色胺吲哚化合物浓度的变化。
Br J Pharmacol Chemother. 1962 Aug;19(1):153-60. doi: 10.1111/j.1476-5381.1962.tb01436.x.
3
Application of seady-state kinetics to studies of the transfer of 5-hydroxyindoleacetic acid from brain to plasma.稳态动力学在5-羟色胺酸从脑到血浆转运研究中的应用。
J Pharmacol Exp Ther. 1967 Nov;158(2):214-8.
4
Origin of 5-hydroxyindoleacetic acid in the spinl fluid.脊髓液中5-羟吲哚乙酸的来源。
Science. 1971 Aug 20;173(3998):738-40. doi: 10.1126/science.173.3998.738.
5
5-Hydroxyindoleacetic acid in rat forebrain and cerebrospinal fluid following dorsal and median midbrain raphe lesions.
Brain Res. 1972 Apr 28;39(2):519-22. doi: 10.1016/0006-8993(72)90456-8.
6
Clearance of amine metabolites from the cerebrospinal fluid: the brain as a "sink".脑脊液中胺类代谢物的清除：作为“汇”的脑
Neurology. 1974 Aug;24(8):772-9. doi: 10.1212/wnl.24.8.772.
7
5-Hydroxyindoleacetic acid in the lumbar fluid: a specific indicator of spinal cord injury.脑脊液中的5-羟吲哚乙酸：脊髓损伤的特异性指标。
Science. 1974 Aug 9;185(4150):527-8. doi: 10.1126/science.185.4150.527.
8
Is cerebrospinal fluid the major avenue for the removal of 5-hydroxyindoleacetic acid from the brain?
Neuropharmacology. 1973 May;12(5):497-9. doi: 10.1016/0028-3908(73)90067-1.
9
Inhibition of 5-hydroxyindoleacetic acid transport from the spinal fluid by probenecid.丙磺舒对脊髓液中5-羟吲哚乙酸转运的抑制作用。
J Pharm Pharmacol. 1971 Jul;23(7):539-40. doi: 10.1111/j.2042-7158.1971.tb08705.x.
10
Transport of material between brain extracellular fluid, brain cells and blood.脑细胞外液、脑细胞与血液之间的物质运输。
Fed Proc. 1974 Sep;33(9):2070-4.
Zotero 插件