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Approaches to stable isotope tracing and in vivo metabolomics in the cancer clinic.

作者信息

Faubert Brandon, Tasdogan Alpaslan

机构信息

Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, IL, USA.

Department of Dermatology, University Hospital Essen & German Cancer Consortium (DKTK), Partner Site Essen, Germany.

出版信息

EMBO J. 2025 May 12. doi: 10.1038/s44318-025-00450-z.

DOI:10.1038/s44318-025-00450-z
PMID:40355557
Abstract
摘要

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本文引用的文献

1
Presenting metabolomics analyses: what's in a number?呈现代谢组学分析：数字背后的含义是什么？
EMBO J. 2024 Oct;43(20):4444-4450. doi: 10.1038/s44318-024-00098-1. Epub 2024 Apr 25.
2
Stable isotope tracing to assess tumor metabolism in vivo.稳定同位素示踪法评估体内肿瘤代谢。
Nat Protoc. 2021 Nov;16(11):5123-5145. doi: 10.1038/s41596-021-00605-2. Epub 2021 Sep 17.
3
Local production of lactate, ribose phosphate, and amino acids within human triple-negative breast cancer.人三阴性乳腺癌内乳酸、磷酸核糖和氨基酸的局部产生。
Med. 2021 Jun 11;2(6):736-754. doi: 10.1016/j.medj.2021.03.009. Epub 2021 Apr 14.
4
Isotope tracing reveals glycolysis and oxidative metabolism in childhood tumors of multiple histologies.同位素示踪技术揭示了多种组织来源的儿童肿瘤中的糖酵解和氧化代谢。
Med. 2021 Apr 9;2(4):395-410. doi: 10.1016/j.medj.2021.01.002. Epub 2021 Feb 23.
5
Quantitative Fluxomics of Circulating Metabolites.循环代谢物的定量通量组学。
Cell Metab. 2020 Oct 6;32(4):676-688.e4. doi: 10.1016/j.cmet.2020.07.013. Epub 2020 Aug 12.
6
Isotope Tracing of Human Clear Cell Renal Cell Carcinomas Demonstrates Suppressed Glucose Oxidation In Vivo.同位素示踪技术在人肾透明细胞癌中的应用表明，肿瘤组织在体内葡萄糖氧化受到抑制。
Cell Metab. 2018 Nov 6;28(5):793-800.e2. doi: 10.1016/j.cmet.2018.07.020. Epub 2018 Aug 23.
7
Metabolomics and Isotope Tracing.代谢组学和同位素示踪。
Cell. 2018 May 3;173(4):822-837. doi: 10.1016/j.cell.2018.03.055.
8
Lactate Metabolism in Human Lung Tumors.人类肺部肿瘤中的乳酸代谢
Cell. 2017 Oct 5;171(2):358-371.e9. doi: 10.1016/j.cell.2017.09.019.
9
Metabolic Heterogeneity in Human Lung Tumors.人类肺部肿瘤中的代谢异质性
Cell. 2016 Feb 11;164(4):681-94. doi: 10.1016/j.cell.2015.12.034. Epub 2016 Feb 4.
10
Applications of stable, nonradioactive isotope tracers in in vivo human metabolic research.稳定的非放射性同位素示踪剂在人体代谢活体研究中的应用。
Exp Mol Med. 2016 Jan 15;48(1):e203. doi: 10.1038/emm.2015.97.