Martinelli Renata, Vannuccini Sofia, Burattini Benedetta, D'Alessandris Quintino Giorgio, D'Ercole Manuela, Izzo Alessandro, Chieffo Daniela P R, Doglietto Francesco, Montano Nicola
Department of Neurosurgery, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, largo A. Gemelli, 8, Rome, 00168, Italy.
Department of Neuroscience, Università Cattolica del Sacro Cuore, Largo F. Vito, 1, Rome, 00168, Italy.
Neurosurg Rev. 2025 May 13;48(1):414. doi: 10.1007/s10143-025-03556-4.
The aim of the present study was to conduct a systematic review regarding the presence and type of psychological comorbidities in patients with trigeminal neuralgia and to determine the potential impact of surgical treatments on these conditions. We reviewed the literature following PRISMA guidelines to identify and critically examine relevant studies. The review question was formulated according to the PICO framework as follows: "For patients affected by trigeminal neuralgia (P) undergoing neuropsychological assessments (I) and potentially undergoing reassessment after surgical treatment (C), is there a correlation between psychological issues and trigeminal neuralgia, and does the treatment of trigeminal neuralgia improve psychological well-being (O)?". The literature search yielded a total of 316 results. After removing duplicates (n = 73), 243 papers were screened. Following title and abstract screening, 222 records were excluded. Ultimately, 11 studies were deemed relevant to the research purpose. To the best of our knowledge, this is the first systematic review highlighting the significant psychological burden of trigeminal neuralgia, including higher risks of sleep, depressive, and anxiety disorders. Surgical treatments effectively alleviate both pain and psychological symptoms, and multidisciplinary approaches combining psychological support and neuro-rehabilitation with medical or surgical care yield better outcomes. Standardizing psychological assessment and treatment methodologies is crucial for optimizing trigeminal neuralgia management. Clinical trial number: Not applicable.
本研究的目的是对三叉神经痛患者心理共病的存在情况及类型进行系统评价，并确定手术治疗对这些情况的潜在影响。我们按照PRISMA指南对文献进行了综述，以识别并严格审查相关研究。综述问题根据PICO框架制定如下：“对于接受神经心理学评估（I）并可能在手术治疗后接受重新评估（C）的三叉神经痛患者（P），心理问题与三叉神经痛之间是否存在关联，以及三叉神经痛的治疗是否能改善心理健康（O）？”文献检索共获得316条结果。去除重复项（n = 73）后，筛选了243篇论文。经过标题和摘要筛选，排除了222条记录。最终，11项研究被认为与研究目的相关。据我们所知，这是第一项强调三叉神经痛显著心理负担的系统评价，包括睡眠、抑郁和焦虑障碍的较高风险。手术治疗可有效缓解疼痛和心理症状，将心理支持和神经康复与药物或手术治疗相结合的多学科方法可产生更好的效果。规范心理评估和治疗方法对于优化三叉神经痛管理至关重要。临床试验编号：不适用。
