皮质酮可拮抗小鼠酒精耐受性的发展。

Cortexolone antagonizes development of alcohol tolerance in mice.

作者信息

Tabakoff B, Yanai J

出版信息

Psychopharmacology (Berl). 1979 Jun 28;64(1):123-4. doi: 10.1007/BF00427357.

DOI:10.1007/BF00427357

Abstract

Mice treated with cortexolone during a period of chronic ethanol feeding displayed significantly less tolerance to a challenge dose of ethanol than mice fed ethanol but not given cortexolone. This glucocorticoid receptor blocker did not alter the hypnotic effects of ethanol in animals not previously given ethanol and no differences were found in ethanol consumption or blood ethanol levels between ethanol-fed mice receiving daily injections of cortexolone and the vehicle-injected controls. It was concluded that cortexolone interferes with the development of tolerance to ethanol.

摘要

在长期喂食乙醇期间用皮质酮处理的小鼠，与只喂食乙醇但未给予皮质酮的小鼠相比，对乙醇挑战剂量的耐受性明显更低。这种糖皮质激素受体阻滞剂不会改变未预先给予乙醇的动物体内乙醇的催眠作用，并且在每日注射皮质酮的乙醇喂养小鼠和注射赋形剂的对照小鼠之间，在乙醇消耗量或血液乙醇水平上未发现差异。得出的结论是，皮质酮会干扰对乙醇耐受性的发展。

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