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Novel non-linear models for clinical trial analysis with longitudinal data: A tutorial using SAS for both frequentist and Bayesian methods.新型非线性模型在临床试验分析中的纵向数据应用：使用 SAS 进行频率派和贝叶斯方法的教程。
Stat Med. 2024 Jul 10;43(15):2987-3004. doi: 10.1002/sim.10089. Epub 2024 May 10.
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Comparison of relative change with effect size metrics in Alzheimer's disease clinical trials.阿尔茨海默病临床试验中相对变化与效应大小指标的比较。
J Neurol Neurosurg Psychiatry. 2023 Dec 14;95(1):2-7. doi: 10.1136/jnnp-2023-331941.
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Two Phase 3 Trials of Gantenerumab in Early Alzheimer's Disease.两项早期阿尔茨海默病甘特纳单抗的 3 期临床试验。
N Engl J Med. 2023 Nov 16;389(20):1862-1876. doi: 10.1056/NEJMoa2304430.
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Donanemab in Early Symptomatic Alzheimer Disease: The TRAILBLAZER-ALZ 2 Randomized Clinical Trial.多奈哌齐治疗早期症状性阿尔茨海默病的随机临床试验。
JAMA. 2023 Aug 8;330(6):512-527. doi: 10.1001/jama.2023.13239.
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Expectations and clinical meaningfulness of randomized controlled trials.随机对照试验的预期和临床意义。
Alzheimers Dement. 2023 Jun;19(6):2730-2736. doi: 10.1002/alz.12959. Epub 2023 Feb 7.
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Lecanemab in Early Alzheimer's Disease.早期阿尔茨海默病中的lecanemab
N Engl J Med. 2023 Jan 5;388(1):9-21. doi: 10.1056/NEJMoa2212948. Epub 2022 Nov 29.
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Proportional constrained longitudinal data analysis models for clinical trials in sporadic Alzheimer's disease.散发性阿尔茨海默病临床试验的比例约束纵向数据分析模型
Alzheimers Dement (N Y). 2022 Apr 5;8(1):e12286. doi: 10.1002/trc2.12286. eCollection 2022.

Letter to the Editor.

作者信息

Li Yan, Schneider Lon S, Wang Guoqiao

机构信息

Department of Neurology, School of Medicine, Washington University, St. Louis, Missouri, USA.

Department of Psychiatry and The Behavioral Sciences, Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

出版信息

Alzheimers Dement. 2025 May;21(5):e70250. doi: 10.1002/alz.70250.

DOI:10.1002/alz.70250
PMID:40356013
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12069004/
Abstract
摘要