Ebden P, Leopold D, Buss D, Smith A P, Routledge P A
Thorax. 1985 Jul;40(7):526-9. doi: 10.1136/thx.40.7.526.
Total plasma and mixed stimulated saliva theophylline concentrations (by high performance liquid chromatography) and free plasma theophylline concentrations (by equilibrium dialysis) were measured in simultaneously collected samples from 32 outpatients receiving chronic oral theophylline treatment, who had received the drug at least two hours before sampling. There was a close relationship between saliva and total plasma theophylline concentration and between total saliva and free plasma concentration. The mean saliva to total plasma drug concentration ratio was 0.69 (SE 0.09) and the mean difference between paired saliva and free plasma concentration was 0.65 (0.17) microgram/ml. It is concluded that stimulated mixed saliva provides a simple, non-invasive method of assessing total (and free) plasma theophylline concentrations during chronic oral treatment. The therapeutic range for saliva, corresponding to the generally accepted total plasma concentration range (10-20 micrograms/ml), is approximately 7-14 micrograms/ml.
对32名接受慢性口服茶碱治疗的门诊患者同时采集的样本进行了检测，通过高效液相色谱法测定了血浆和混合刺激唾液中的茶碱总浓度，通过平衡透析法测定了游离血浆茶碱浓度，这些患者在采样前至少两小时已服用该药物。唾液与血浆茶碱总浓度之间以及总唾液与游离血浆浓度之间存在密切关系。唾液与血浆药物总浓度的平均比值为0.69（标准误0.09），配对的唾液与游离血浆浓度之间的平均差值为0.65（0.17）微克/毫升。结论是，刺激混合唾液为慢性口服治疗期间评估血浆茶碱总浓度（和游离浓度）提供了一种简单、非侵入性的方法。唾液的治疗范围对应于普遍接受的血浆总浓度范围（10 - 20微克/毫升），约为7 - 14微克/毫升。
