Letavay Amy, Amin Sheyar, Pressman Elliott, Smith Teagen, Guerrero Waldo R, Vakharia Kunal, Mokin Maxim
Department of Neurosurgery and Brain Repair, University of South Florida, Tampa, FL, USA.
Research Methodology and Biostatistics Core, University of South Florida, Tampa, FL USA.
Interv Neuroradiol. 2025 May 13:15910199251341647. doi: 10.1177/15910199251341647.
BackgroundMost of endovascular thrombectomy (EVT) procedures are performed outside of clinical trials, thus the data available from such trials is often not reflective of real-world practice. How specific indications for EVT or new techniques evolve or impact procedural outcomes in individual patients remains largely unknown.MethodsFrom 2013 to 2023, demographic, clinical and procedural data was collected on consecutive first 20 EVT procedures at the beginning of each year. Trends in utilization of thrombectomy devices and correlations with procedural outcomes were investigated.ResultsThere was a significant difference in the distribution of target occlusion sites (<0.001) with a trend towards a higher proportion of distal occlusions treated with EVT in more recent years. Aspiration-first approach to EVT became more frequent whereas the frequency of stent retriever-first approach decreased ( < 0.001). Average duration of the EVT procedure decreased dramatically ( < 0.001, = 0.7). In 2013-2015 versus 2022-2023, mean duration of thrombectomy was 128 and 41 min, respectively. However, the number of passes, rates of first pass effect, final TICI 2b/3 and TICI 2c/3 reperfusion remained largely unchanged ( > 0.1 for each metric).ConclusionsOur analysis demonstrates continuous changes in target population of patients with acute stroke treated with EVT and procedural techniques used by operators. While the average duration of the procedure has decreased dramatically, its technical success has remained largely unchanged. This indicates continuous unmet need for future innovation in this field of neurointervention.
背景
大多数血管内血栓切除术(EVT)操作是在临床试验之外进行的,因此此类试验所获得的数据往往不能反映实际临床实践情况。EVT的特定适应症或新技术如何演变,以及对个体患者手术结果有何影响,目前仍 largely未知。
方法
从2013年至2023年,每年年初连续收集前20例EVT手术的人口统计学、临床和手术数据。研究了血栓切除术器械的使用趋势及其与手术结果的相关性。
结果
目标闭塞部位的分布存在显著差异(<0.001),近年来,EVT治疗的远端闭塞比例有上升趋势。EVT的先抽吸方法变得更加频繁,而先使用支架取栓器的方法频率下降(<0.001)。EVT手术的平均持续时间大幅下降(<0.001,r = 0.7)。在2013 - 2015年与2022 - 2023年期间,血栓切除术的平均持续时间分别为128分钟和41分钟。然而,操作次数、首次通过效应率、最终TICI 2b/3和TICI 2c/3再灌注率基本保持不变(各指标均>0.1)。
结论
我们的分析表明,接受EVT治疗的急性中风患者目标人群以及操作者所使用的手术技术在持续变化。虽然手术的平均持续时间大幅下降,但其技术成功率基本保持不变。这表明在神经介入这一领域,未来创新仍存在持续未满足的需求。