Shah D V, Suttie J W
Thromb Res. 1985 Jul 1;39(1):43-7. doi: 10.1016/0049-3848(85)90120-3.
Injection of plasma from a vitamin K-deficient hypoprothrombinemic rat into a normal rat causes an increase in plasma prothrombin activity in the recipient rat. Maximum concentrations of the factor responsible for this response (coagulopoietin) are present in the plasma of rats fed a vitamin K-deficient diet for 7 days and do not increase as the period of deficiency is increased. The coagulopoietin activity of plasma from individual rats is variable, but similar activity was observed when multiple recipient rats received the same donor plasma.
将维生素K缺乏的低凝血酶原血症大鼠的血浆注入正常大鼠体内，会使受体大鼠血浆中的凝血酶原活性增加。负责这种反应的因子（促凝素）的最大浓度存在于喂食维生素K缺乏饮食7天的大鼠血浆中，并且不会随着缺乏期的延长而增加。个体大鼠血浆的促凝素活性是可变的，但当多只受体大鼠接受相同的供体血浆时，观察到了相似的活性。
