Penile remodeling, Sonic hedgehog, and fibrosis.
作者信息
Podlasek Carol A
机构信息
Departments of Urology, Physiology, Bioengineering, and Biochemistry, University of Illinois at Chicago, Chicago, IL 60612, United States.
出版信息
J Sex Med. 2025 May 10;22(5):668-670. doi: 10.1093/jsxmed/qdaf048.
Abstract
摘要
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本文引用的文献
1
SHH regulates penile morphology and smooth muscle through a mechanism involving BMP4 and GREM1.音猬因子（SHH）通过一种涉及骨形态发生蛋白4（BMP4）和生长调节致癌基因1（GREM1）的机制来调节阴茎形态和平滑肌。
J Sex Med. 2024 Apr 30;21(5):379-390. doi: 10.1093/jsxmed/qdae016.
2
BMP4 and GREM1 are targets of SHH signaling and downstream regulators of collagen in the penis.骨形态发生蛋白4（BMP4）和Gremlin1（GREM1）是音猬因子（SHH）信号通路的靶点以及阴茎中胶原蛋白的下游调节因子。
J Sex Med. 2024 Apr 30;21(5):367-378. doi: 10.1093/jsxmed/qdae015.
3
Pathway Enrichment Analysis of Microarray Data Fom Human Penis of Diabetic and Peyronie's Patients, in Comparison With Diabetic Rat Erectile Dysfunction Models.糖尿病和阴茎硬结症患者阴茎组织芯片基因表达谱资料通路富集分析，并与糖尿病大鼠勃起功能障碍模型进行比较。
J Sex Med. 2022 Jan;19(1):37-53. doi: 10.1016/j.jsxm.2021.10.004. Epub 2021 Nov 25.
4
Optimization of Sonic Hedgehog Delivery to the Penis from Self-Assembling Nanofiber Hydrogels to Preserve Penile Morphology after Cavernous Nerve Injury.自组装纳米纤维水凝胶向阴茎传递 Sonic Hedgehog 的优化，以在海绵体神经损伤后保留阴茎形态。
Nanomedicine. 2019 Aug;20:102033. doi: 10.1016/j.nano.2019.102033. Epub 2019 Jun 5.
5
Erectile Dysfunction in Young Men-A Review of the Prevalence and Risk Factors.年轻人勃起功能障碍：患病率和风险因素的综述。
Sex Med Rev. 2017 Oct;5(4):508-520. doi: 10.1016/j.sxmr.2017.05.004. Epub 2017 Jun 20.
6
Monomeric gremlin is a novel vascular endothelial growth factor receptor-2 antagonist.单体gremlin是一种新型血管内皮生长因子受体-2拮抗剂。
Oncotarget. 2016 Jun 7;7(23):35353-68. doi: 10.18632/oncotarget.9286.
7
Sonic hedgehog delivery from self-assembled nanofiber hydrogels reduces the fibrotic response in models of erectile dysfunction.从自组装纳米纤维水凝胶中递送音猬因子可降低勃起功能障碍模型中的纤维化反应。
Acta Biomater. 2016 Mar 1;32:89-99. doi: 10.1016/j.actbio.2016.01.014. Epub 2016 Jan 14.
8
Sonic hedgehog protein is decreased and penile morphology is altered in prostatectomy and diabetic patients.前列腺切除术和糖尿病患者的 Sonic 刺猬蛋白减少，阴茎形态改变。
PLoS One. 2013 Aug 14;8(8):e70985. doi: 10.1371/journal.pone.0070985. eCollection 2013.
9
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J Sex Med. 2013 May;10(5):1240-50. doi: 10.1111/j.1743-6109.2012.02930.x. Epub 2012 Sep 20.
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A large bioactive BMP ligand with distinct signaling properties is produced by alternative proconvertase processing.一种具有独特信号特性的大型生物活性 BMP 配体是通过选择性前转化酶加工产生的。
Sci Signal. 2012 Apr 3;5(218):ra28. doi: 10.1126/scisignal.2002549.
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