Abuhulayqah Shaima, Aldulijan Fajar Abdulrazzak, Turkistani Alaa Nabil, Almulhim Albatoul Fahad, Almulhim Cereen Fahad, Bashir Shahid, Ali Eman Nassim
Department of Adult Neurology, King Fahad Hofuf Hospital, Hofuf, Saudi Arabia.
Department of Family Medicine, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia.
Front Neurol. 2025 Apr 28;16:1534746. doi: 10.3389/fneur.2025.1534746. eCollection 2025.
Stroke is one of the most common causes of disability and mortality worldwide. In Saudi Arabia, it is a crucial health issue. Ischemic stroke is the most common type of stroke in this area, and understanding its relationship with hemoglobin (Hgb) levels is vital. To date, no study has established an exact relationship between Hgb levels and stroke severity. This study assessed the association between Hgb levels and the severity of acute ischemic stroke (AIS) at presentation.
We conducted a retrospective study of patients admitted and diagnosed with AIS between 2013 and 2017. The exclusion criteria included other stroke types (such as hemorrhagic or venous infarction), patients with a history of internal bleeding, and pregnant and lactating women. The patients were divided into three groups based on Hgb levels: low, average, and high. Correlations were analyzed between these groups and the National Institutes of Health Stroke Scale (NIHSS) scores, stroke outcomes at discharge (cured, improved, or mortality decreased), and stroke subtype, as determined and classified by the TOAST classification criteria.
The Pearson correlation coefficient showed a weak positive correlation between Hgb levels and NIHSS scores. Neither stroke outcomes nor stroke types showed significant correlations with mean Hgb level.
The results of this retrospective study on a small cohort of patients diagnosed with AIS indicate that higher Hgb levels at hospital admission are associated with greater stroke severity, as measured by the NIHSS score. However, no significant effect was observed on stroke outcome at discharge or the TOAST classification.
中风是全球致残和致死的最常见原因之一。在沙特阿拉伯，这是一个关键的健康问题。缺血性中风是该地区最常见的中风类型，了解其与血红蛋白（Hgb）水平的关系至关重要。迄今为止，尚无研究确定Hgb水平与中风严重程度之间的确切关系。本研究评估了就诊时Hgb水平与急性缺血性中风（AIS）严重程度之间的关联。
我们对2013年至2017年间收治并诊断为AIS的患者进行了一项回顾性研究。排除标准包括其他中风类型（如出血性或静脉梗死）、有内出血病史的患者以及孕妇和哺乳期妇女。根据Hgb水平将患者分为三组：低、中、高。分析了这些组与美国国立卫生研究院卒中量表（NIHSS）评分、出院时的中风结局（治愈、好转或死亡率降低）以及根据TOAST分类标准确定和分类的中风亚型之间的相关性。
Pearson相关系数显示Hgb水平与NIHSS评分之间存在弱正相关。中风结局和中风类型与平均Hgb水平均无显著相关性。
这项对一小群诊断为AIS的患者进行的回顾性研究结果表明，入院时较高的Hgb水平与更高的中风严重程度相关，这通过NIHSS评分来衡量。然而，未观察到对出院时的中风结局或TOAST分类有显著影响。
