Yang Xiao, Zhao Kai-Jun, Liu Jian-Min
Department of Neurosurgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Neurovascular Centre, Changhai Hospital, Naval Medical University, Shanghai, China.
Front Neurol. 2025 Apr 28;16:1553455. doi: 10.3389/fneur.2025.1553455. eCollection 2025.
To report a novel clinical entity, "Multi-regional Sequential Pain Syndrome" (MRSPS), and evaluate the relationship between hypoperfusion, cryptogenic vertebral artery dissection (CVAD), and MRSPS.
A 59-year-old female patient, with a chronic MRSPS condition spanning 10-30 years, underwent a comprehensive diagnostic evaluation including cranial CTA, MRI, DSA, and CT perfusion, culminating in the identification of CVAD via dynamic contrast-enhanced computed tomography (DCE-CT). The treatment strategy integrated repairing CVADs with stent implantation to address the hypoperfusion and MRSPS.
Following intervention, hypoperfusion achieved complete improvement, and the patient achieved the complete resolution of pain and vertigo, with the modified Rankin Scale (mRS) score of 0 at the 1-year follow-up, signifying full neurological recovery.
CVADs, a key cause of brain tissue hypoperfusion in MRSPS, can be effectively treated by repair to alleviate the syndrome.
报告一种新的临床病症“多区域序贯性疼痛综合征”（MRSPS），并评估低灌注、隐匿性椎动脉夹层（CVAD）与MRSPS之间的关系。
一名患有慢性MRSPS达10至30年的59岁女性患者接受了全面的诊断评估，包括头颅CT血管造影（CTA）、磁共振成像（MRI）、数字减影血管造影（DSA）和CT灌注成像，最终通过动态对比增强计算机断层扫描（DCE-CT）确诊为CVAD。治疗策略包括通过支架植入修复CVAD，以解决低灌注和MRSPS问题。
干预后，低灌注完全改善，患者疼痛和眩晕完全缓解，1年随访时改良Rankin量表（mRS）评分为0，表明神经功能完全恢复。
CVAD是MRSPS中脑组织低灌注的关键原因，通过修复可有效治疗CVAD以缓解该综合征。
