Richter Gregor, Hammed Ali, Ismail Omar, Omran Safwan, Rishan Dina, Hirsch Sara, Tanislav Christian
Diakonie Hospital Jung Stilling Siegen, Germany.
German Heart Center of the Charité Department of Cardiothoracic and Vascular Surgery, Germany.
Neuroradiol J. 2025 Apr 28:19714009251339091. doi: 10.1177/19714009251339091.
Vertebrobasilar artery occlusion (VBAO) is a life-threatening condition with often nonspecific symptoms, making early diagnosis challenging. Timely intervention is crucial, especially in cases involving distal vertebral artery stenosis. A 65-year-old male presented with acute vertigo, dizziness, and visual disturbances, along with ipsilateral sixth cranial nerve palsy. His medical history included a treated abdominal aortic aneurysm, hypercholesterolemia, and hypertension. CT angiography (CTA) revealed an occlusion in the V4 segment of the right vertebral artery. CT perfusion imaging showed minimal perfusion delay in the right brainstem. The patient received intravenous thrombolysis (IVT) with tenecteplase, followed by mechanical thrombectomy (MT), partial recanalization was achieved. However, digital subtraction angiography (DSA) identified a critical stenosis (>90%) responsible for the occlusion, consistent with arteriosclerotic disease. Following intravenous administration of 500 mg acetylsalicylic acid, a Biotronik Orsiro 2.25 × 9 mm drug-eluting stent was placed, achieving complete recanalization (eTICI 3). Neurologic symptoms resolved completely post-intervention, and the patient received 300 mg clopidogrel. He was discharged with an MRS score of 0 within 3 days. This case highlights the effectiveness of a multimodal approach (IVT, MT, and stenting) in treating distal vertebral artery occlusion (Mori Type C). Early diagnosis and timely endovascular intervention led to rapid symptom resolution and complete neurological recovery. Follow-up ultrasound at 4 months confirmed good bilateral vertebral artery perfusion without restenosis, supporting the potential long-term benefits of this multimodal treatment approach. This case underscores the importance of advanced imaging for early detection and the role of thrombectomy and stenting in optimizing patient outcomes.
椎基底动脉闭塞(VBAO)是一种危及生命的疾病,症状往往不具特异性,早期诊断具有挑战性。及时干预至关重要,尤其是在涉及椎动脉远端狭窄的病例中。一名65岁男性出现急性眩晕、头晕和视觉障碍,伴有同侧第六颅神经麻痹。他的病史包括已治疗的腹主动脉瘤、高胆固醇血症和高血压。CT血管造影(CTA)显示右椎动脉V4段闭塞。CT灌注成像显示右脑桥灌注延迟最小。患者接受了替奈普酶静脉溶栓(IVT),随后进行了机械取栓(MT),实现了部分再通。然而,数字减影血管造影(DSA)发现了导致闭塞的严重狭窄(>90%),与动脉硬化疾病一致。静脉注射500毫克阿司匹林后,植入了一枚Biotronik Orsiro 2.25×9毫米药物洗脱支架,实现了完全再通(eTICI 3级)。干预后神经症状完全缓解,患者接受了300毫克氯吡格雷治疗。他在3天内以改良Rankin量表(MRS)评分为0出院。本病例突出了多模式方法(IVT、MT和支架置入)治疗椎动脉远端闭塞(Mori C型)的有效性。早期诊断和及时的血管内干预导致症状迅速缓解和神经功能完全恢复。4个月后的随访超声证实双侧椎动脉灌注良好,无再狭窄,支持了这种多模式治疗方法的潜在长期益处。本病例强调了先进成像技术在早期检测中的重要性以及取栓和支架置入在优化患者预后方面的作用。