Nxumalo Celenkosini T, Buthelezi Usangiphile, Chiya Hlolisile, Makgobole Mokgadi U, Mpofana Nomakhosi, Mgwaba Themba, Luvuno Zamasomi
Department of Research Development and Postgraduate Support, Office of the DVC Research and Innovation, University of the Western Cape, Cape Town, South Africa.
Centre for Rural Health, School of Nursing and Public Health, University of KwaZulu-Natal, Durban, South Africa.
J Public Health Afr. 2025 Apr 21;16(1):691. doi: 10.4102/jphia.v16i1.691. eCollection 2025.
The Joint United Nations Programme on HIV/AIDS (UNAIDS) set targets for 95% of people living with human immunodeficiency virus (HIV) infection to know their status, 95% to receive antiretroviral therapy (ART) and 95% to achieve viral suppression. These targets mirror the 90-90-90 targets that were aimed to be met by 2020 to end AIDS as a public health threat by 2030.
The study aims to synthesise evidence on recommendations, best practices and challenges in achieving 90-90-90 escalated to 95-95-95 fast-track targets in sub-Saharan Africa.
The review included empirical evidence from sub-Saharan Africa.
We followed Arksey and O'Malley's methodological framework for this scoping review. A systematic search of relevant articles was conducted using electronic databases such as Scopus, EBSCOHost, PubMed, Science Direct and Sabinet. The results were reported using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flow diagram.
There were 6943 relevant study titles that were identified from the five databases. Following duplicates removal, title and abstract screening, 31 articles were included for full-text review. A combination of qualitative, quantitative and mixed methods studies were included.
The 90-90-90 targets have been achieved in part, but challenges remain, particularly for key and vulnerable populations. Even as successes and challenges towards '90-90-90 by 2020' are outlined, new fast-track '95-95-95 by 2030' targets have been established because of concerns that the original targets may not have achieved epidemic control.
The findings of this review have implications for policy and practice related to interventions to facilitate the realisation of HIV epidemic control as outlined by the UNAIDS 95-95-95 treatment cascade.
联合国艾滋病规划署（UNAIDS）设定了目标，即95%的人类免疫缺陷病毒（HIV）感染者知晓自身感染状况，95%接受抗逆转录病毒疗法（ART），95%实现病毒抑制。这些目标与原计划到2020年实现、到2030年消除艾滋病作为公共卫生威胁的90-90-90目标相呼应。
本研究旨在综合关于在撒哈拉以南非洲实现提升至95-95-95快速通道目标的90-90-90过程中的建议、最佳实践及挑战的证据。
该综述纳入了来自撒哈拉以南非洲的实证证据。
我们遵循阿克斯西和奥马利的方法框架进行此项范围综述。使用Scopus、EBSCOHost、PubMed、Science Direct和Sabinet等电子数据库对相关文章进行系统检索。结果采用系统评价和Meta分析的首选报告项目（PRISMA）流程图进行报告。
从这五个数据库中识别出6943个相关研究标题。在去除重复项、进行标题和摘要筛选后，31篇文章被纳入全文评审。纳入了定性、定量和混合方法研究。
90-90-90目标已部分实现，但挑战依然存在，尤其是对关键和脆弱人群而言。尽管概述了实现“2020年达到90-90-90”的成功与挑战，但由于担心原目标可能无法实现疫情控制，已确立了新的快速通道“2030年达到95-95-95”目标。
本综述的结果对与促进实现UNAIDS 95-95-95治疗级联所概述的HIV疫情控制干预措施相关的政策和实践具有启示意义。
