Liu Lusheng, Ge Danxia, Lin Yumeng, Han Zhongyu, Zhao Heng, Cao Liqin, Wu Xi, Ma Guizhi
Department of Acupuncture and Moxibustion, Shanghai Traditional Chinese Medicine (TCM)-Integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Shanghai Clinical Medical College of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Front Immunol. 2025 Apr 28;16:1516473. doi: 10.3389/fimmu.2025.1516473. eCollection 2025.
The unique physiological structure of women has led to a variety of diseases that have attracted the attention of many people in recent years. Disturbances in the reproductive system microenvironment lead to the progression of various female tumours and pregnancy disorders. Numerous studies have shown that epigenetic modifications crucially influence both oogenesis and foetal development. m6A, a modification at the mRNA level, consists of three parts, namely, writers, erasers, and readers, which are involved in several biological functions, such as the nucleation and stabilisation of mRNAs, thereby regulating the development of reproductive system diseases. In this manuscript, we delineate the constituents of m6A, their biological roles, and advancements in understanding m6A within the maternal-foetal immunological context. In addition, we summarise the mechanism of m6A in gynaecological diseases and provide a new perspective for targeting m6A to delay the progression of reproductive system diseases in clinical practice.
女性独特的生理结构导致了多种疾病，近年来这些疾病引起了许多人的关注。生殖系统微环境的紊乱会导致各种女性肿瘤和妊娠疾病的进展。大量研究表明，表观遗传修饰对卵子发生和胎儿发育都至关重要。m6A是一种mRNA水平的修饰，由三部分组成，即写入器、擦除器和读取器，它们参与多种生物学功能，如mRNA的成核和稳定，从而调节生殖系统疾病的发展。在本手稿中，我们阐述了m6A的组成部分、它们的生物学作用以及在母胎免疫背景下对m6A的认识进展。此外，我们总结了m6A在妇科疾病中的作用机制，并为在临床实践中靶向m6A以延缓生殖系统疾病的进展提供了新的视角。
