Dong Qiannan, Zhao Xubin, Zhu Changze, Ruan Jianping, Chen Cheng
Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Xi'an 710000, China.
Department of General Dentistry, College of Stomatology, Xi'an Jiaotong University, Xi'an 710000, China.
Int J Mol Sci. 2025 Jun 12;26(12):5620. doi: 10.3390/ijms26125620.
Bone-related diseases significantly diminish human happiness, adversely impacting overall quality of life. Optimizing bone tissue repair remains a prominent focus within the field of bone tissue regenerative medicine. N6-methyladenosine (m6A) is one of the most prevalent epigenetic modifications found in eukaryotic mRNA and non-coding RNA. The functions of m6A involve diverse components, including "Writers", "Erasers", and "Readers". Numerous studies have demonstrated that m6A plays a crucial role in the exchange of information and coordination among various cell types, bioactive factors, and the microenvironment, influencing the progression of diverse physiological and pathological processes within the human body. In recent years, many functions and molecular pathways associated with m6A have been identified. This review primarily discusses the relationship between the three components of m6A and osteogenesis, as well as other key genes and pathways involved in this process. Additionally, we provide an in-depth elucidation of the interaction network between m6A modifications, micro-RNAs, and long non-coding RNAs. In the final section, we address the current limitations in m6A and osteogenesis research and explore the prospects for the diagnosis and treatment of bone-related diseases.
骨相关疾病显著降低人类幸福感，对整体生活质量产生不利影响。优化骨组织修复仍然是骨组织再生医学领域的一个突出重点。N6-甲基腺苷（m6A）是真核生物mRNA和非编码RNA中最普遍的表观遗传修饰之一。m6A的功能涉及多种成分，包括“书写器”“擦除器”和“读取器”。大量研究表明，m6A在各种细胞类型、生物活性因子和微环境之间的信息交换与协调中起关键作用，影响人体内各种生理和病理过程的进展。近年来，已确定了许多与m6A相关的功能和分子途径。本综述主要讨论m6A的三个组成部分与成骨作用之间的关系，以及参与这一过程的其他关键基因和途径。此外，我们深入阐明了m6A修饰、微小RNA和长链非编码RNA之间的相互作用网络。在最后一部分，我们阐述了m6A与成骨作用研究目前的局限性，并探讨了骨相关疾病诊断和治疗的前景。
