Newton P E, Latendresse J R, Mattie D R, Pfledderer C
Toxicol Appl Pharmacol. 1985 Sep 30;80(3):534-41. doi: 10.1016/0041-008x(85)90399-0.
The administration of 4-ipomeanol, [0, 10 (LD), and 25 (HD) mg/kg, ip], to rats resulted in dose-dependent degeneration and necrosis of the nonciliated (Clara) and ciliated epithelial cells of the terminal bronchioles. More extensive necrosis of the terminal bronchiolar epithelium, with exposure of the basement membrane, was produced in the HD group. Repair of the terminal bronchiolar epithelium was complete within 10 days. Alveolar clearance of 51Cr labeled polystyrene latex microspheres was analyzed through 40 days postinstillation by nonlinear regression for a double exponential model. Alveolar clearance during phase 1 (Days 2 to 6) was delayed and significantly decreased in both the LD and HD groups. Alveolar clearance during phase 2 (Days 10 to 40) was significantly decreased only in the HD group. The decreased alveolar clearance in HD subjects was long term and did not correlate with the return of morphologically normal appearing Clara and ciliated cell structure.
给大鼠腹腔注射4-异戊烯醇（剂量分别为0、10mg/kg（低剂量组）和25mg/kg（高剂量组）），可导致终末细支气管的无纤毛（克拉拉）和纤毛上皮细胞出现剂量依赖性变性和坏死。高剂量组终末细支气管上皮坏死更广泛，基底膜暴露。终末细支气管上皮在10天内完全修复。通过双指数模型的非线性回归分析了51Cr标记的聚苯乙烯乳胶微球在滴注后40天内的肺泡清除率。在第1阶段（第2至6天），低剂量组和高剂量组的肺泡清除率均延迟且显著降低。在第2阶段（第10至40天），仅高剂量组的肺泡清除率显著降低。高剂量组肺泡清除率降低是长期的，且与形态学上看似正常的克拉拉细胞和纤毛细胞结构的恢复无关。
