Liang Huikai, Pan Kelun, Wang Jiayi, Lin Jianqing
Department of Breast and Thyroid Surgery, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.
The Second Clinical College of Fujian Medical University, Quanzhou, China.
Front Nutr. 2025 Apr 28;12:1533636. doi: 10.3389/fnut.2025.1533636. eCollection 2025.
An increasing number of studies suggests an association between systemic inflammation, nutritional status, and cancer. However, the relationship between the prevalence of breast cancer (BC) and the neutrophil-percentage-to-albumin ratio (NPAR), a recently identified biomarker of inflammation, is not well established. Therefore, this study aims to investigate the relationship between BC risk and the NPAR.
This study included 18,726 participants from the National Health and Nutrition Examination Survey (NHANES) conducted between 2001 and 2018. The NPAR was used to assess inflammation and nutritional status. Statistical methods such as multivariate logistic regression, subgroup analysis, and restricted cubic spline (RCS) analysis were conducted to investigate the influence of NPAR on the prevalence of BC. In addition, propensity score matching was employed to further validate the findings.
The logistic regression results showed that the prevalence of breast cancer is significantly associated with the NPAR (OR = 1.05; 95% CI = 1.02-1.09, = 0.003). In comparison to participants in the lowest quartile, Q1, the prevalence of breast cancer increased by 5% for those in Q2 ( = 0.745), 3% for those in Q3 ( = 0.032), and 38% for those in Q4 ( = 0.018) with a higher NPAR. In addition, subgroup and RCS analyses showed that the NPAR and BC prevalence were positively correlated. Furthermore, a significant association was observed between the NPAR and marital status. The significance of traits was assessed using mean decrease accuracy (MDA) and mean decrease impurity (MDI). These measures of random forest modeling showed that NPAR is one of the major factors affecting the prevalence of BC. Furthermore, linear analysis demonstrated a correlation between a high NPAR and increased total testosterone and sex hormone-binding globulin (SHBG) levels.
A significant association was observed between a high NPAR and a higher prevalence of breast cancer, which could be attributable to sex hormone levels. This finding suggests that the NPAR may serve as a biomarker for BC in adult women in the US.
越来越多的研究表明全身炎症、营养状况与癌症之间存在关联。然而，乳腺癌（BC）患病率与中性粒细胞百分比与白蛋白比值（NPAR）（一种最近发现的炎症生物标志物）之间的关系尚未明确确立。因此，本研究旨在探讨BC风险与NPAR之间的关系。
本研究纳入了2001年至2018年期间进行的美国国家健康与营养检查调查（NHANES）中的18726名参与者。NPAR用于评估炎症和营养状况。采用多因素逻辑回归、亚组分析和受限立方样条（RCS）分析等统计方法来研究NPAR对BC患病率的影响。此外，采用倾向得分匹配法进一步验证研究结果。
逻辑回归结果显示，乳腺癌患病率与NPAR显著相关（OR = 1.05；95% CI = 1.02 - 1.09，P = 0.003）。与处于最低四分位数（Q1）的参与者相比，NPAR较高的Q2参与者的乳腺癌患病率增加了5%（P = 0.745），Q3参与者增加了3%（P = 0.032），Q4参与者增加了38%（P = 0.018）。此外，亚组分析和RCS分析表明NPAR与BC患病率呈正相关。此外，还观察到NPAR与婚姻状况之间存在显著关联。使用平均准确度下降（MDA）和平均杂质下降（MDI）评估特征的显著性。这些随机森林建模指标表明NPAR是影响BC患病率的主要因素之一。此外，线性分析表明高NPAR与总睾酮和性激素结合球蛋白（SHBG）水平升高之间存在相关性。
观察到高NPAR与较高的乳腺癌患病率之间存在显著关联，这可能归因于性激素水平。这一发现表明NPAR可能作为美国成年女性BC的生物标志物。
