某些有机磷化合物对三种两栖动物胚胎的毒性和致畸作用。

The toxic and teratogenic effects of selected organophosphorus compounds on the embryos of three species of amphibians.

作者信息

Fulton M H, Chambers J E

出版信息

Toxicol Lett. 1985 Aug;26(2-3):175-80. doi: 10.1016/0378-4274(85)90163-8.

Abstract

The toxic and teratogenic effects of 4 organophosphorus compounds (phenyl saliginen cyclic phosphate (PSCP), leptophos-oxon (LPTO), tri-o-tolyl phosphate (TOTP), and paraoxon (PXN] were investigated in the embryos of 3 species of frogs. Developmental abnormalities were observed in surviving embryos of each of the 3 species following exposure to PSCP at concentrations as low as 500 ppb for 24 h. LPTO, while being toxic to gray treefrog embryos at concentrations as low as 2.2 ppm, did not induce developmental abnormalities. TOTP and PXN were neither toxic nor teratogenic at concentrations of 10 ppm and 100 ppm respectively.

摘要

研究了4种有机磷化合物（苯基水杨基环磷酸酯（PSCP）、倍硫磷-氧磷（LPTO）、磷酸三邻甲苯酯（TOTP）和对氧磷（PXN））对3种蛙胚胎的毒性和致畸作用。在暴露于低至500 ppb的PSCP 24小时后，3种蛙的存活胚胎中均观察到发育异常。LPTO虽然对灰树蛙胚胎的毒性低至2.2 ppm，但未诱导发育异常。TOTP和PXN在浓度分别为10 ppm和100 ppm时既无毒性也无致畸性。