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“胎盘植入谱系疾病”时代的前置胎盘未排出:两例期待治疗病例报告及管理方案建议

Retained non-previa placenta in the era of "placenta accreta spectrum": a report of two cases managed expectantly and a proposed plan for management.

作者信息

Ramadan Mohamad K, El-Zein Nouhad, Jomaa Murchida, Zeidan Abir, El Tal Rana, Badr Dominique A

机构信息

Division of Maternal-Fetal-Medicine, Department of Obstetrics and Gynecology, Makassed General Hospital, Beirut, Lebanon.

Department of Obstetrics and Gynecology, Makassed General Hospital, Beirut, Lebanon.

出版信息

Front Med (Lausanne). 2025 Apr 28;12:1504491. doi: 10.3389/fmed.2025.1504491. eCollection 2025.

DOI:10.3389/fmed.2025.1504491
PMID:40357271
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12066307/
Abstract

Retained placenta (RP) is the absence of placental expulsion within 30 min of neonatal delivery. It is an obstetric complication affecting 0.5-4.8% of all vaginal deliveries. We report two cases in which the patients were primiparous. Patients were initially kept at the hospital under close observation. The lack of spontaneous detachment and the absence of bleeding prompted us to resort to an expectant approach approved by both patients. A decrease in B-hCG levels was followed by a steady decrease in placental size and the resumption of regular menses. The management of RP should be individualized according to hospital resources, patient fertility desire, sonographic characteristics, the presence of hemorrhage, and hemodynamic stability. RP should prompt the mobilization of resources needed for managing postpartum hemorrhage (PPH), which might ensue without notice. Manual removal of the placenta (MROP) has been recommended for managing RP regardless of hemorrhage or retention etiology. MROP, however, might initiate massive bleeding, infections, prolonged hospitalization, the need for curettage and hysterectomy. Moreover, if MROP is attempted in an unidentified placenta accreta spectrum (PAS), it might initiate life-threatening hemorrhage, necessitating the performance of hemostatic interventions, including emergent hysterectomy. Serious considerations should be given to mitigate the indiscriminate use of MROP in the era of the "PAS epidemic."

摘要

胎盘滞留(RP)是指新生儿分娩后30分钟内胎盘未排出。它是一种产科并发症,影响所有阴道分娩的0.5-4.8%。我们报告两例初产妇病例。患者最初留在医院密切观察。由于缺乏自发剥离且无出血,我们采取了经患者双方认可的期待疗法。β-人绒毛膜促性腺激素(B-hCG)水平下降后,胎盘大小稳步减小,月经恢复正常。RP的管理应根据医院资源、患者生育意愿、超声特征、出血情况以及血流动力学稳定性进行个体化处理。RP应促使调动处理产后出血(PPH)所需的资源,PPH可能毫无征兆地发生。无论出血或滞留病因如何,均建议采用人工剥离胎盘(MROP)来处理RP。然而,MROP可能引发大量出血、感染、住院时间延长、需要刮宫和子宫切除术。此外,如果在未识别的胎盘植入谱系(PAS)中尝试MROP,可能引发危及生命的出血,需要进行包括紧急子宫切除术在内的止血干预。在“PAS流行”时代,应认真考虑减少MROP的滥用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96e9/12066307/21c2504d611e/fmed-12-1504491-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96e9/12066307/d9e9450a8181/fmed-12-1504491-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96e9/12066307/de7c3f17c305/fmed-12-1504491-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96e9/12066307/21c2504d611e/fmed-12-1504491-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96e9/12066307/d9e9450a8181/fmed-12-1504491-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96e9/12066307/de7c3f17c305/fmed-12-1504491-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96e9/12066307/21c2504d611e/fmed-12-1504491-g003.jpg

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本文引用的文献

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Placenta accreta spectrum conservative management and coagulopathy: case series and systematic review.胎盘植入谱系疾病的保守管理与凝血功能障碍:病例系列及系统性综述。
Ultrasound Obstet Gynecol. 2024 Jun;63(6):731-737. doi: 10.1002/uog.27547. Epub 2024 May 16.
2
Pathologically diagnosed placenta accreta spectrum without placenta previa: a systematic review and meta-analysis.病理性诊断为胎盘植入谱系疾病而无前置胎盘:系统评价和荟萃分析。
Am J Obstet Gynecol MFM. 2023 Aug;5(8):101027. doi: 10.1016/j.ajogmf.2023.101027. Epub 2023 May 19.
3
Conservative Management for Retained Products of Conception in Late Pregnancy.
晚期妊娠中妊娠物残留的保守治疗
Healthcare (Basel). 2023 Jan 5;11(2):168. doi: 10.3390/healthcare11020168.
4
Long-term gynecological complications after conservative treatment of placenta accreta spectrum.胎盘植入谱系疾病保守治疗后的长期妇科并发症
Front Med (Lausanne). 2022 Oct 28;9:992215. doi: 10.3389/fmed.2022.992215. eCollection 2022.
5
Risk of Subsequent Hysterectomy after Expectant Management in the Treatment of Placenta Accreta Spectrum Disorders.期待治疗在胎盘植入谱系疾病治疗中后继发子宫切除术的风险。
Medicina (Kaunas). 2022 May 19;58(5):678. doi: 10.3390/medicina58050678.
6
Retained products of conception (RPOC) following delivery without placenta previa: Which patients with RPOC show postpartum hemorrhage?产后无前置胎盘残留妊娠产物(RPOC):哪些 RPOC 患者会出现产后出血?
Placenta. 2022 Jun 24;124:12-17. doi: 10.1016/j.placenta.2022.05.004. Epub 2022 May 10.
7
Expectant Management of Placenta Accreta Spectrum Disorders.胎盘植入谱系疾病的期待管理
Surg J (N Y). 2021 Jun 3;7(Suppl 1):S2-S6. doi: 10.1055/s-0040-1722240. eCollection 2021 Dec.
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Failure of placental detachment in accreta placentation is associated with excessive fibrinoid deposition at the utero-placental interface.胎盘植入部位的胎盘剥离失败与胎盘界面的纤维蛋白样物质过度沉积有关。
Am J Obstet Gynecol. 2022 Feb;226(2):243.e1-243.e10. doi: 10.1016/j.ajog.2021.08.026. Epub 2021 Aug 28.
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