衰老对慢性肾脏病患者丙氨酸氨基转移酶水平及衰弱的影响：埃塞俄比亚西北部基于实验室的横断面研究
Impact of aging on alanine aminotransferase levels and frailty in chronic kidney disease patients: laboratory-based cross-sectional study in Northwest Ethiopia.
作者信息
Agidew Melaku Mekonnen, Mulu Anemut Tilahun, Teklemariam Awgichew Behaile, Mengstie Misganaw Asmamaw, Melake Addisu, Zewde Edgeit Abebe, Muche Zelalem Tilahun, Dagnew Samuel Berihun, Baye Nega Dagnew, Adane Bezawit, Walle Muluken, Derso Girma
机构信息
Department of Biomedical Science, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Department of Clinical Pharmacy, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
出版信息
Front Med (Lausanne). 2025 Apr 28;12:1524459. doi: 10.3389/fmed.2025.1524459. eCollection 2025.
BACKGROUND
Chronic kidney disease (CKD) is a non-communicable progressive condition that leads to a gradual decline in kidney functions, resulting in different complications. Serum alanine aminotransferase (ALT) is an important biomarker for diagnosing liver comorbidities. However, ALT levels in CKD patients could be affected by aging. Despite this challenge, there is a scarcity of data on the effect of aging on frailty and ALT levels in CKD patients in Ethiopia. Thus, this study aimed to assess the impact of aging on serum levels of ALT, the magnitude of frailty, and the associated factors among CKD patients in different age groups.
METHODS
A hospital-based cross-sectional study involving 120 CKD patients was conducted in Bahir Dar, Ethiopia. Data were collected using structured questionnaire. Blood pressure, anthropometric parameters, ALT levels, and frailty were assessed according to standard procedures. Data were analyzed using SPSS version 25. Pearson's correlation analysis, multiple linear analysis, and logistic regression analysis were performed to identify predictors of ALT levels and frailty, with a statistical significance level of < 0.05.
RESULTS
The serum level of ALT was significantly lower in CKD patients aged ≥ 46 years compared to CKD patients aged 18-45 years. The magnitude of frailty in CKD patients aged 18-45 and ≥ 46 years was 8.5% (95% CI: 1.4-15.6) and 34.4% (95% CI: 22.5-46.4), respectively, and was significantly associated with ALT levels. Factors such as age category (AOR: 0.16, 95% CI: 0.04-0.60) and hypertension (HTN) (AOR: 10.16, 95% CI: 1.03-99.90) were significantly associated with frailty.
CONCLUSION
The serum level of ALT was significantly correlated with age and frailty in CKD patients. Thus, ALT levels can be used as a biomarker for aging and frailty. The age of CKD patients and HTN were factors significantly associated with frailty.
背景
慢性肾脏病（CKD）是一种非传染性的进行性疾病，会导致肾功能逐渐下降，引发各种并发症。血清丙氨酸氨基转移酶（ALT）是诊断肝脏合并症的重要生物标志物。然而，CKD患者的ALT水平可能会受到年龄的影响。尽管存在这一挑战，但在埃塞俄比亚，关于衰老对CKD患者虚弱程度和ALT水平影响的数据却很匮乏。因此，本研究旨在评估衰老对不同年龄组CKD患者血清ALT水平、虚弱程度及相关因素的影响。
方法
在埃塞俄比亚的巴赫达尔进行了一项基于医院的横断面研究，纳入了120例CKD患者。通过结构化问卷收集数据。根据标准程序评估血压、人体测量参数、ALT水平和虚弱程度。使用SPSS 25版进行数据分析。进行Pearson相关性分析、多元线性分析和逻辑回归分析，以确定ALT水平和虚弱程度的预测因素，统计学显著性水平为<0.05。
结果
与18 - 45岁的CKD患者相比，年龄≥46岁的CKD患者血清ALT水平显著降低。18 - 45岁和≥46岁的CKD患者虚弱程度分别为8.5%（95%CI：1.4 - 15.6）和34.4%（95%CI：22.5 - 46.4），且与ALT水平显著相关。年龄类别（调整后比值比[AOR]：0.16，95%CI：0.04 - 0.60）和高血压（HTN）（AOR：10.16，95%CI：1.03 - 99.90）等因素与虚弱程度显著相关。
结论
CKD患者的血清ALT水平与年龄和虚弱程度显著相关。因此，ALT水平可作为衰老和虚弱的生物标志物。CKD患者的年龄和HTN是与虚弱程度显著相关的因素。
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