Poulter N R, Khaw K T, Mugambi M, Peart W S, Rose G, Sever P
Trans R Soc Trop Med Hyg. 1985;79(3):389-92. doi: 10.1016/0035-9203(85)90390-6.
The blood pressure patterns of three Kenyan communities have been studied: 861 members of the Luo tribe in a rural community, 281 members of the Kamba tribe in a rural community and 310 "urban" Luo living in Nairobi. The slope of linear regression of blood pressure with age was significantly different in each population: rural Luo had the smallest rise with age and urban Luo had the largest rise with age, while the Kamba tribe were in between. The differences could not be accounted for by weight. Urinary electrolyte data showed rural Luo had the lowest sodium ratios (sodium/creatinine, sodium/potassium) and the highest potassium/creatinine ratio: urban Luo had the highest sodium and lowest potassium ratios and rural Kamba had values in between. The differences in blood pressures between the two groups of the same tribe in different environments (rural and urban Luo) were far greater than those between different genetic groups (Kamba and Luo) underlining the importance of environmental factor(s) in the determination of arterial pressure. Furthermore, these data support the theory that the dietary intake of sodium and potassium are the major influential environmental factors affecting blood pressure.
一个农村社区的861名卢奥部落成员、一个农村社区的281名坎巴部落成员以及生活在内罗毕的310名“城市”卢奥人。每个群体中血压随年龄变化的线性回归斜率显著不同：农村卢奥人随年龄增长的血压升高幅度最小，城市卢奥人随年龄增长的血压升高幅度最大，而坎巴部落则介于两者之间。这些差异无法用体重来解释。尿电解质数据显示，农村卢奥人的钠比率（钠/肌酐、钠/钾）最低，钾/肌酐比率最高；城市卢奥人的钠比率最高，钾比率最低，农村坎巴人的数值则介于两者之间。同一部落的两组人在不同环境（农村和城市卢奥人）中的血压差异远大于不同基因群体（坎巴人和卢奥人）之间的差异，这突出了环境因素在动脉血压决定中的重要性。此外，这些数据支持了以下理论：钠和钾的饮食摄入量是影响血压的主要环境因素。
