Gevorkian E S, Iavroian Zh V, Panosian G A
Ukr Biokhim Zh (1978). 1985 Jul-Aug;57(4):78-81.
When isolating protein components of chromatin from the rat liver phospholipids are found in the fraction of nonhistone proteins but not in that of histone. Administration of hydrocortisone to animals evokes a reliable increase of the phospholipids of hydrocortisone to animals evokes a reliable increase of the phospholipids amount in the preparations of chromatin and labile-bound nonhistone proteins. In this case the fraction of phosphatidylcholine lowers considerably with a simultaneous increase of sphingomyelin and phosphatidylethanolamine. It is supposed that phospholipid metabolism in chromatin is controlled by hormones, which may be significant for mechanisms of the genetic apparatus activation by steroid hormones.
从大鼠肝脏中分离染色质的蛋白质成分时，发现磷脂存在于非组蛋白部分，而不存在于组蛋白部分。给动物注射氢化可的松会使染色质和不稳定结合的非组蛋白蛋白质制剂中的磷脂含量可靠增加。在这种情况下，磷脂酰胆碱部分会大幅降低，同时鞘磷脂和磷脂酰乙醇胺增加。据推测，染色质中的磷脂代谢受激素控制，这可能对类固醇激素激活遗传装置的机制具有重要意义。
