Gevorkian E S, Demirkhanian D O, Iavroian Zh V, Artsruni I G, Akopian N R
Yerevan State University.
Ukr Biokhim Zh (1999). 2001 May-Jun;73(3):51-4.
In vivo the action of insulin on rat liver chromatin phospholipid composition was investigated. It was shown that the hormone led to reliable increase (nearly 20%) of total phospholipid content. The same phenomenon was shown also in the fraction of active chromatin while the phospholipids content of non-active chromatin didn't changed. It was also shown that the content of three from six phospholipid fractions altered under the insulin action. The content of sphingomyelin and phosphatidilethanolamine increased and the quantity of phosphatidylinositol decreased under the hormone action. The decrease of monophosphoinositides content was accompanied by the reliable increase of triphosphoinositides amount. It was suggested that the fractions of chromatin polyphosphoinositides were redistributed under the action of insulin.
在体内研究了胰岛素对大鼠肝脏染色质磷脂组成的作用。结果表明，该激素导致总磷脂含量可靠增加（近20%）。在活性染色质部分也出现了同样的现象，而非活性染色质的磷脂含量没有变化。还表明，在胰岛素作用下，六种磷脂组分中的三种含量发生了改变。在激素作用下，鞘磷脂和磷脂酰乙醇胺的含量增加，而磷脂酰肌醇的量减少。单磷酸肌醇含量的降低伴随着三磷酸肌醇量的可靠增加。有人提出，在胰岛素作用下，染色质多磷酸肌醇组分发生了重新分布。
