Holstein A F, Sauerwein D, Schirren U
Urologe A. 1985 Jul;24(4):208-15.
Testicular biopsies from 22 paraplegic men were studied by light and electron microscopy. The investigations of semithin sections by a special standardized method revealed that normal spermatogenesis occurred in only one patient, whereas in 21 patients severe disturbance of spermatogenesis was found. The germinal epithelium displayed a decrease of spermatogenic cells, an increase of degenerating cells, especially of spermatids, and a release of large groups of premature germ cells. Cross sectioned tubules often showed no patent lumina. As revealed by electron microscopical investigations the spermatids show malformations in most cases of the head and acrosome, rarely of the tail. Decreased spermatogenic activity occurred in various degrees in each of the 21 men. There is no evidence that any specific form of spermatogenic disturbance exists typical of spinal cord injury. No obvious relationship was found between the degree of spermatogenic disturbance and duration or level of the spinal cord lesion or incidence of urinary tract infection.
对22名截瘫男性的睾丸活检组织进行了光镜和电镜研究。采用一种特殊的标准化方法对半薄切片进行研究发现，只有1例患者发生正常精子发生，而在21例患者中发现了严重的精子发生障碍。生精上皮显示生精细胞减少，尤其是精子细胞在内的退化细胞增多，大量未成熟生殖细胞释放。横切的曲细精管常无通畅的管腔。电镜研究显示，在大多数病例中，精子细胞的头部和顶体存在畸形，尾部畸形少见。21名男性的生精活性均有不同程度降低。没有证据表明存在脊髓损伤特有的任何特定形式的生精障碍。未发现生精障碍程度与脊髓损伤的持续时间、水平或尿路感染发生率之间有明显关系。
