Zhou Yuli, Wang Fang, Feng Siren, Li Mengsen, Zhu Mingyue
Key Laboratory of Tropical Translational Medicine, Ministry of Education and Hainan Provincial Key Laboratory of Carcinogenesis and Intervention, Hainan Medical University, 3 Xueyuan Road, Longhua District, Haikou, 571199, Hainan, People's Republic of China.
Department of Medical Oncology, Second Affiliated Hospital, Hainan Medical University, Haikou, 570216, China.
Discov Oncol. 2025 May 13;16(1):749. doi: 10.1007/s12672-025-02573-5.
Deubiquitinating enzymes (DUBs) are a class of crucial peptidyl hydrolases within the ubiquitin system, playing a significant role in reversing and strictly regulating ubiquitination, which is essential for various biological processes such as protein stability and cellular signal transduction. Ubiquitin-specific protease 39 (USP39) is an important member of the DUBs family. Recent studies have revealed that USP39 is involved in the regulation of multiple cellular activities including cell proliferation, migration, invasion, apoptosis, and DNA damage repair. USP39 also plays a significant role in the development and progression of various cancers. It is believed that USP39 is a unique enzyme that controls the ubiquitin process and is closely associated with the occurrence and progression of many cancers, including hepatocellular, lung, gastric, breast, and ovarian cancer. This review summarizes the structural and functional aspects of USP39 and its research advancements in tumors, investigates the key molecular mechanisms related to USP39, and provides references for tumor diagnosis and treatment.
去泛素化酶（DUBs）是泛素系统中的一类关键肽基水解酶，在逆转和严格调控泛素化过程中发挥着重要作用，而泛素化对于蛋白质稳定性和细胞信号转导等各种生物学过程至关重要。泛素特异性蛋白酶39（USP39）是DUBs家族的重要成员。最近的研究表明，USP39参与调控多种细胞活动，包括细胞增殖、迁移、侵袭、凋亡和DNA损伤修复。USP39在各种癌症的发生和发展中也起着重要作用。据信，USP39是一种控制泛素化过程的独特酶，与许多癌症的发生和发展密切相关，包括肝细胞癌、肺癌、胃癌、乳腺癌和卵巢癌。本综述总结了USP39的结构和功能方面及其在肿瘤中的研究进展，探讨了与USP39相关的关键分子机制，并为肿瘤诊断和治疗提供参考。
