Clinical Medical College, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610075, P.R. China.
Department of Infectious Diseases, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610072, P.R. China.
Int J Oncol. 2024 Sep;65(3). doi: 10.3892/ijo.2024.5676. Epub 2024 Aug 2.
The Hippo signaling pathway plays a pivotal role in regulating cell growth and organ size. Its regulatory effects on hepatocellular carcinoma (HCC) encompass diverse aspects, including cell proliferation, invasion and metastasis, tumor drug resistance, metabolic reprogramming, immunomodulatory effects and autophagy. Yes‑associated protein 1 (YAP1), a potent transcriptional coactivator and a major downstream target tightly controlled by the Hippo pathway, is influenced by various molecules and pathways. The expression of YAP1 in different cell types within the liver tumor microenvironment exerts varying effects on tumor outcomes, warranting careful consideration. Therefore, research on YAP1‑targeted therapies merits attention. This review discusses the composition and regulation mechanism of the Hippo/YAP1 signaling pathway and its relationship with HCC, offering insights for future research and cancer prevention strategies.
Hippo 信号通路在调节细胞生长和器官大小方面发挥着关键作用。其对肝细胞癌（HCC）的调控作用涉及多个方面，包括细胞增殖、侵袭和转移、肿瘤耐药性、代谢重编程、免疫调节作用和自噬。Yes 相关蛋白 1（YAP1）是一种强有力的转录共激活因子，也是 Hippo 通路严格控制的主要下游靶标，受多种分子和途径的影响。YAP1 在肝肿瘤微环境中不同类型的细胞中的表达对肿瘤结局产生不同的影响，值得仔细考虑。因此，针对 YAP1 的靶向治疗研究值得关注。本文讨论了 Hippo/YAP1 信号通路的组成和调节机制及其与 HCC 的关系，为未来的研究和癌症预防策略提供了思路。
