Um Yoo Jin, Cho In Young, Koo Hye Yeon, Park Yong-Moon Mark, Kim Kyung Mee, Lee Chung Eun, Han Kyungdo
Department of Medical Education, Seoul National University College of Medicine, Seoul, Republic of Korea.
Department of Family Medicine and Supportive Care Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Osteoporos Int. 2025 May 13. doi: 10.1007/s00198-025-07519-9.
In this retrospective cohort study, people with intellectual disabilities (ID) had higher risks of fractures, including any fractures, vertebral fractures, and hip fractures, compared to those without ID. The risk was especially pronounced in younger adults (20-39 years), emphasizing the importance of targeted healthcare interventions in individuals with ID.
Life expectancies of individuals with ID have increased over the past few decades. We aimed to evaluate the risk of any fractures, vertebral fractures, and hip fractures in people with ID compared to those without ID.
This retrospective cohort study analysed Korean National Disability Registry data with the Korean National Health Insurance Service database. A total of 3,815,545 individuals who underwent national health examinations in 2009 were followed until 2020. Cox-proportional hazard analyses were performed to estimate the hazard ratios (HRs) of any fractures, vertebral fractures, and hip fractures in individuals with compared to those without ID with adjustment for covariates.
During a mean follow-up period of 10.0 years, among 3582 individuals with ID, there were 207 cases of any fractures, 47 cases of vertebral fractures, and 27 cases of hip fractures. The multivariable-adjusted hazard ratios for risk of any fractures, vertebral fractures, and hip fractures in the ID group compared to those without ID were 1.69 (95% CI 1.47-1.94), 2.07 (95% CI 1.55-2.75), and 3.01 (95% CI 2.07-4.39), respectively. In subgroup analysis, individuals with ID aged 20-39 years had higher risk of fractures compared to those in older age groups.
Individuals with ID are at an increased risk of any fractures, vertebral fractures, and hip fractures compared to those without ID. Healthcare professionals should be aware of the elevated risk of fractures in this population.
在这项回顾性队列研究中，与无智力残疾（ID）的人相比，有智力残疾的人发生骨折的风险更高，包括任何骨折、椎体骨折和髋部骨折。这种风险在年轻成年人（20 - 39岁）中尤为明显，强调了针对有智力残疾个体进行有针对性医疗干预的重要性。
在过去几十年中，有智力残疾个体的预期寿命有所增加。我们旨在评估有智力残疾的人与无智力残疾的人相比发生任何骨折、椎体骨折和髋部骨折的风险。
这项回顾性队列研究分析了韩国国家残疾登记数据与韩国国民健康保险服务数据库。对2009年接受全国健康检查的3815545名个体进行随访直至2020年。进行Cox比例风险分析以估计有智力残疾个体与无智力残疾个体相比发生任何骨折、椎体骨折和髋部骨折的风险比（HRs），并对协变量进行调整。
在平均10.0年的随访期内，3582名有智力残疾的个体中，有207例发生任何骨折，47例发生椎体骨折，27例发生髋部骨折。与无智力残疾个体相比，有智力残疾组发生任何骨折、椎体骨折和髋部骨折风险的多变量调整风险比分别为1.69（95%CI 1.47 - 1.94）、2.07（95%CI 1.55 - 2.75）和3.01（95%CI 2.07 - 4.39）。在亚组分析中，20 - 39岁有智力残疾的个体与年龄较大组相比发生骨折的风险更高。
与无智力残疾的人相比，有智力残疾的个体发生任何骨折、椎体骨折和髋部骨折的风险增加。医疗保健专业人员应意识到该人群骨折风险的升高。
