Bernth Jensen Jens Magnus, Dinh Khoa Manh, Hindhede Lotte, Erikstrup Lise Tornvig, Hansen Annette Gudmann, Hymøller Kirstine Mejlstrup, Ostrowski Sisse Rye, Pedersen Ole B V, Christiansen Stig Hill, Sørensen Uffe B Skov, Thiel Steffen, Erikstrup Christian
Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.
Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.
Med Microbiol Immunol. 2025 May 13;214(1):23. doi: 10.1007/s00430-025-00833-3.
IgG antibodies against terminal galactose-α-1,3-galactose (anti-αGal antibodies) are naturally occurring in humans, but their origins remain poorly understood. These antibodies target various microorganisms including Staphylococcus aureus, a common nasal commensal and the major cause of skin abscesses. This study investigates the impact of S. aureus colonization and abscess events on plasma anti-αGal antibody levels. We measured plasma anti-αGal antibody levels using a quantitative immunoassay in: (i) 101 pairs of healthy individuals with and without nasal S. aureus colonization, (ii) 106 healthy individuals before and after abscess formation, and (iii) 43 patients with recurrent skin abscesses compared with 75 patient controls and 60 healthy controls. We observed a 35% reduction (95%CI: 7-54%) in anti-αGal antibody levels in nasal S. aureus carriers. Conversely, we found a 30% increase (95%CI: 4-66%) in individuals within 187 days post-skin abscess, and patients with recurrent skin abscesses exhibited 81% higher (95%CI: 14-190%) levels than patient controls, and 110% higher (95%CI: 39-230%) than healthy controls. This study suggests that skin abscesses lead to elevated plasma anti-αGal antibody levels and that these antibodies might convey or correlate with mucosal immunity to S. aureus.
针对末端半乳糖-α-1,3-半乳糖的IgG抗体（抗αGal抗体）在人类中天然存在，但其来源仍知之甚少。这些抗体靶向多种微生物，包括金黄色葡萄球菌，它是一种常见的鼻腔共生菌，也是皮肤脓肿的主要病因。本研究调查了金黄色葡萄球菌定植和脓肿事件对血浆抗αGal抗体水平的影响。我们使用定量免疫测定法测量了以下人群的血浆抗αGal抗体水平：（i）101对有和没有鼻腔金黄色葡萄球菌定植的健康个体；（ii）106名健康个体在脓肿形成前后；（iii）43例复发性皮肤脓肿患者，并与75例患者对照和60名健康对照进行比较。我们观察到鼻腔金黄色葡萄球菌携带者的抗αGal抗体水平降低了35%（95%CI：7-54%）。相反，我们发现皮肤脓肿后187天内的个体抗αGal抗体水平升高了30%（95%CI：4-66%），复发性皮肤脓肿患者的抗αGal抗体水平比患者对照高81%（95%CI：14-190%），比健康对照高110%（95%CI：39-230%）。本研究表明，皮肤脓肿会导致血浆抗αGal抗体水平升高，并且这些抗体可能传递或与针对金黄色葡萄球菌的黏膜免疫相关。
