Sun Huan, Zhai Qiaoli, Liu Juan, Shi Kourong, Fan Wei
Department of Pharmacy, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, 200137, China.
Clin Transl Oncol. 2025 May 13. doi: 10.1007/s12094-025-03920-2.
The gut microbiota is a complex and dynamic community of microorganisms that reside in the gastrointestinal tract, playing a critical role in the host. It produces many metabolites, such as bile acids, which play an important role in the metabolism of the host. One area of particular interest is its involvement in the development and treatment of cancer. Carcinogens, which are substances known to promote cancer formation and development, are present in various sources in our daily lives, including cigarettes, barbecues, and moldy foods. The types, amounts, and metabolism of carcinogens have been closely linked to cancer risk, underscoring the importance of understanding their interplay with the gut microbiota. Numerous studies have demonstrated significant differences in the composition and function of the gut microbiota in individuals with cancer compared to healthy individuals. The gut microbiota and its metabolites have been shown to influence the metabolism of various carcinogens, thereby affecting cancer progression. While much attention has been paid to the relationship between the gut microbiota and cancer risk, the potential interplay between the gut microbiota and carcinogens has received less focus. This review aims to emphasize the importance of exploring the interplay between the gut microbiota with its metabolites and carcinogens in cancer development and therapy. By uncovering the mechanisms of the interplay, new approaches for cancer prevention and treatment can be developed.
肠道微生物群是一个复杂且动态的微生物群落，栖息于胃肠道，在宿主中发挥着关键作用。它产生许多代谢产物，如胆汁酸，这些代谢产物在宿主代谢中起着重要作用。一个特别受关注的领域是其在癌症发生发展及治疗中的作用。致癌物是已知可促进癌症形成和发展的物质，存在于我们日常生活的各种来源中，包括香烟、烧烤食品和发霉食物。致癌物的类型、数量及其代谢与癌症风险密切相关，这凸显了了解它们与肠道微生物群相互作用的重要性。大量研究表明，与健康个体相比，癌症患者肠道微生物群的组成和功能存在显著差异。肠道微生物群及其代谢产物已被证明会影响各种致癌物的代谢，从而影响癌症进展。虽然肠道微生物群与癌症风险之间的关系已受到广泛关注，但肠道微生物群与致癌物之间的潜在相互作用却较少受到关注。本综述旨在强调探索肠道微生物群及其代谢产物与致癌物在癌症发生发展和治疗中的相互作用的重要性。通过揭示相互作用的机制，可以开发出癌症预防和治疗的新方法。
