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新一代测序质量倡议以及临床和公共卫生实验室面临的挑战。

The Next-Generation Sequencing Quality Initiative and Challenges in Clinical and Public Health Laboratories.

作者信息

Cherney Blake, Diaz Ariel, Chavis Camby, Ghattas Christopher, Evans Diana, Arambula Diego, Stang Heather

出版信息

Emerg Infect Dis. 2025 May;31(13):14-17. doi: 10.3201/eid3113.241175.

DOI:10.3201/eid3113.241175
PMID:40359008
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12078536/
Abstract

The Next-Generation Sequencing (NGS) Quality Initiative addresses laboratory challenges faced when performing NGS by developing tools and resources to build a robust quality management system. Here, we illustrate how those products support laboratories in navigating complex regulatory environments and quality-related challenges while implementing NGS effectively in an evolving landscape.

摘要

下一代测序（NGS）质量倡议通过开发工具和资源来构建强大的质量管理体系，以应对进行NGS时面临的实验室挑战。在此，我们阐述了这些产品如何在不断变化的环境中有效实施NGS的同时，支持实验室应对复杂的监管环境和与质量相关的挑战。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06ca/12078536/4f1fae2e19bf/24-1175-F4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06ca/12078536/aa98d85be73d/24-1175-F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06ca/12078536/16f597eab9a4/24-1175-F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06ca/12078536/87ae4a8ac78f/24-1175-F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06ca/12078536/4f1fae2e19bf/24-1175-F4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06ca/12078536/aa98d85be73d/24-1175-F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06ca/12078536/16f597eab9a4/24-1175-F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06ca/12078536/87ae4a8ac78f/24-1175-F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06ca/12078536/4f1fae2e19bf/24-1175-F4.jpg

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Exploring current challenges in the technologist workforce of clinical genomics laboratories.探索临床基因组学实验室技术人员队伍当前面临的挑战。
Genet Med Open. 2023 Mar 27;1(1):100806. doi: 10.1016/j.gimo.2023.100806. eCollection 2023.
2
Closing the gap: Oxford Nanopore Technologies R10 sequencing allows comparable results to Illumina sequencing for SNP-based outbreak investigation of bacterial pathogens.缩小差距：牛津纳米孔技术 R10 测序能够与 Illumina 测序相媲美，可用于基于 SNP 的细菌病原体暴发调查。
J Clin Microbiol. 2024 May 8;62(5):e0157623. doi: 10.1128/jcm.01576-23. Epub 2024 Mar 5.
3
Sequencing by avidity enables high accuracy with low reagent consumption.
高亲和力测序可实现高精度和低试剂消耗。
Nat Biotechnol. 2024 Jan;42(1):132-138. doi: 10.1038/s41587-023-01750-7. Epub 2023 May 25.
4
Practical Guidance to Implementing Quality Management Systems in Public Health Laboratories Performing Next-Generation Sequencing: Personnel, Equipment, and Process Management (Phase 1).实施高通量测序公共卫生实验室质量管理体系的实用指南：人员、设备和过程管理（第 1 阶段）。
J Clin Microbiol. 2019 Jul 26;57(8). doi: 10.1128/JCM.00261-19. Print 2019 Aug.
5
Assuring the Quality of Next-Generation Sequencing in Clinical Microbiology and Public Health Laboratories.确保临床微生物学和公共卫生实验室中下一代测序的质量。
J Clin Microbiol. 2016 Dec;54(12):2857-2865. doi: 10.1128/JCM.00949-16. Epub 2016 Aug 10.