Huang Qianli, Shao Changhui, Wei Wei, Ou Shan
Department of Anesthesiology, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Department of Anesthesiology, Chengdu integrated TCM & Western Medicine Hospital, Chengdu, Sichuan, China.
PLoS One. 2025 May 13;20(5):e0323342. doi: 10.1371/journal.pone.0323342. eCollection 2025.
Lidocaine is increasingly used for surgical patients requiring general anesthesia. However, its clinical benefits on postoperative recovery quality are not well established. Our main objective aims to summarize the evidence regarding the effectiveness of perioperative lidocaine infusion on postoperative subjective quality of recovery (QoR).
This protocol will be conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P) guideline. This systematic review will include randomized controlled trials (RCTs) from their inception until December 31st, 2024 with no language restrictions. The major databases including PubMed, Embase, and the Cochrane library will be comprehensively searched and supplemented by a hand searching reference lists of all included articles. Searches will involve studies assessing the efficacy of the perioperative lidocaine infusion for improving postoperative QoR, in comparison to placebo, or on treatment. The two authors will independently screen studies, extract study data and assess bias risk of the studies. The subjective QoR (QoR-15, QoR-40) on postoperative day 1-3 will be defined as primary outcome, whereas secondary outcomes will include morphine consumption, incidence of postoperative nausea and vomiting, time to first bowel movement, time to first flatus, and length of hospital stay. A meta-analysis will be performed using Review Manager 5.3 software. Sensitivity analyses, subgroup analysis and publication bias will also be conducted. The evidence quality of pooled results will be assessed by the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach.
This review and meta-analysis is anticipated to provide the evidence for the role of intravenous lidocaine on the subjective quality of recovery after surgery. In addition, the findings from this review will help clinicians with developing effective and safe perioperative anesthetic management regimens for surgery patients.
PROSPERO registration number: CRD42024585866.
利多卡因越来越多地用于需要全身麻醉的手术患者。然而，其对术后恢复质量的临床益处尚未明确确立。我们的主要目的是总结围手术期输注利多卡因对术后主观恢复质量（QoR）有效性的证据。
本方案将按照系统评价与Meta分析方案的首选报告项目（PRISMA-P）指南进行。本系统评价将纳入从开始至2024年12月31日的随机对照试验（RCT），无语言限制。将全面检索包括PubMed、Embase和Cochrane图书馆在内的主要数据库，并通过手工检索所有纳入文章的参考文献列表进行补充。检索将涉及评估围手术期输注利多卡因与安慰剂相比或与治疗相比改善术后QoR疗效的研究。两位作者将独立筛选研究、提取研究数据并评估研究的偏倚风险。术后第1至3天的主观QoR（QoR-15、QoR-40）将被定义为主要结局，而次要结局将包括吗啡用量、术后恶心呕吐发生率、首次排便时间、首次排气时间和住院时间。将使用Review Manager 5.3软件进行Meta分析。还将进行敏感性分析、亚组分析和发表偏倚分析。汇总结果的证据质量将采用推荐分级评估、制定与评价（GRADE）方法进行评估。
本综述和Meta分析预计将为静脉注射利多卡因在术后主观恢复质量方面的作用提供证据。此外，本综述的结果将有助于临床医生为手术患者制定有效且安全的围手术期麻醉管理方案。
PROSPERO注册号：CRD42024585866。
