静脉注射利多卡因对术后认知功能障碍的影响：系统评价和荟萃分析。

The effect of intravenous lidocaine on postoperative cognitive dysfunction: a systematic review and meta-analysis.

机构信息

Department of Anesthesiology, Fengxian People's Hospital, Fengxian County, Xuzhou City, 221700, Jiangsu Province, China.

Department of Anesthesiology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, 201399, China.

出版信息

BMC Anesthesiol. 2023 Sep 5;23(1):299. doi: 10.1186/s12871-023-02202-0.

BACKGROUND

Postoperative cognitive dysfunction (POCD) has been reported as a significant complication in elderly patients. Various methods have been proposed for reducing the incidence and severity of POCD. Intravenous lidocaine administration has been reported in the literature to reduce POCD, but the effect of lidocaine remains controversial.

METHODS

We screened Medline, Embase, Cochrane Library, and China National Knowledge Infrastructure (up to April 2022) databases following a search strategy for intravenous lidocaine on POCD. We also screened related bibliographies on lidocaine for POCD. Ten articles comprising 1517 patients were selected and analyzed. We divided the postoperative follow-up period as follows: short term (<30 days), medium term (30-90 days), and long term (>90 days).

OUTCOMES

We found that lidocaine could attenuate the overall incidence of POCD, especially in the short term. There were no differences between lidocaine and placebo on the overall severity of POCD.

CONCLUSION

Lidocaine administered intravenously could attenuate the overall incidence of POCD and its severity in the short term.

背景

术后认知功能障碍（POCD）已被报道为老年患者的一种严重并发症。已经提出了各种方法来降低 POCD 的发生率和严重程度。文献中报道静脉内给予利多卡因可降低 POCD，但利多卡因的效果仍存在争议。

方法

我们按照静脉内利多卡因对 POCD 的检索策略，筛选了 Medline、Embase、Cochrane 图书馆和中国国家知识基础设施（截至 2022 年 4 月）数据库。我们还对利多卡因治疗 POCD 的相关文献进行了筛选。选择并分析了 10 篇文章，共 1517 例患者。我们将术后随访期分为以下几类：短期（<30 天）、中期（30-90 天）和长期（>90 天）。