Qiu Yahong, Zhu Lixia, Cai Wenyan, Zhu Lijuan
The Key Laboratory of Developmental Genes and Human Disease, Department of Histology and Embryology, School of Medicine, Southeast University, Nanjing, Jiangsu 210009, China.
Patent Examination Cooperation (JIANGSU) Center of the Patent Office, China National Intellectual Property Administration (CNIPA), Suzhou, Jiangsu 215163, China.
ACS Chem Neurosci. 2025 Jun 4;16(11):2013-2023. doi: 10.1021/acschemneuro.5c00193. Epub 2025 May 13.
Depression is a potentially life-threatening psychiatric disorder that affects the physical and mental health of millions of individuals worldwide. It can manifest at any stage of life, inducing profound emotional despondency, negative cognitions, and, in severe cases, suicidal ideation, often accompanied by physical symptoms, bringing a significant burden on both families and society. Brain-derived neurotrophic factor (BDNF), a member of the neurotrophic factor family, is widely expressed in the central nervous system (CNS), particularly in regions, such as the hippocampus and cortex. Numerous studies have shown that an imbalance or inadequate conversion of pro-brain-derived neurotrophic factor (proBDNF) into its mature form, mature BDNF (mBDNF), may impair neuronal plasticity, which is crucial to the pathogenesis of depression. This paper provides a comprehensive review of the neurotrophic mechanisms implicated in depression, covering the location, expression, and release of BDNF; the relationship between proBDNF, mBDNF, and depression; and the downstream signaling pathways triggered by BNDF binding to its receptors. This review aims to provide a theoretical foundation for understanding the pathogenesis and clinical treatment of depression.
抑郁症是一种可能危及生命的精神障碍，影响着全球数百万人的身心健康。它可在生命的任何阶段出现，引发深刻的情绪低落、消极认知，严重时还会出现自杀念头，常伴有身体症状，给家庭和社会都带来沉重负担。脑源性神经营养因子（BDNF）是神经营养因子家族的一员，在中枢神经系统（CNS）中广泛表达，尤其是在海马体和皮质等区域。大量研究表明，前脑源性神经营养因子（proBDNF）向其成熟形式——成熟BDNF（mBDNF）的转化失衡或不足，可能会损害神经元可塑性，而这对抑郁症的发病机制至关重要。本文全面综述了与抑郁症相关的神经营养机制，涵盖BDNF的定位、表达和释放；proBDNF、mBDNF与抑郁症之间的关系；以及BDNF与其受体结合所触发的下游信号通路。本综述旨在为理解抑郁症的发病机制和临床治疗提供理论基础。
