Wang Jing, Ren Yaoyao, Qu Shengtao
Department of Ophthalmology, Shengjing Hospital of China Medical University. 36 Sanhao Street, Heping District, 110004 Shenyang, Liaoning, PR China.
Department of Otolaryngology Head and Neck Surgery, Shengjing Hospital of China Medical University, 36 Sanhao Street, Heping District, 110004 Shenyang, Liaoning, PR China.
Phytomedicine. 2025 Jul 25;143:156648. doi: 10.1016/j.phymed.2025.156648. Epub 2025 May 12.
Aging is a complex phenomenon involving oxidative stress, inflammation, and cellular damage subsequently leading to various disorders, such as cardiovascular diseases, neurodegenerative disorders, diabetes, and cancer. Sirtuin (SIRT) proteins are one of the major molecular factors that affect human aging. Sirtuins are a class of NAD-dependent enzymes that control oxidative stress response, DNA damage repair, inflammation and metabolism, all of which are involved in aging and age-related diseases.
The objective of this review is to elucidate the potential role of SIRT in the aging process and modulation of SIRT pathway through selected phytochemicals like Curcumin, Resveratrol, Quercetin, and Kaempferol.
Studies convincedly revealed that SIRT pathway represents a promising avenue for extending the human health span and addressing age-related conditions. Phytochemicals like Curcumin, Resveratrol, Quercetin, and Kaempferol have shown excellent potential to mediate aging effects through their potent antioxidant, anti-inflammatory, and regulatory activities. These potent bioactive compounds enhance oxidative stress response, genomic integrity, neuroprotective and anti-inflammatory activities through SIRT pathway modulation. Furthermore, in addition to antiaging effects, other therapeutic benefits are also associated with each compound including nervous disorders, cancer, and metabolic disorders are also briefly highlighted. Studies reported convincing evidence that Curcumin, Resveratrol, Quercetin, and Kaempferol, effectively modulate SIRT expression/activity leading to improved cell stress tolerance, reduced oxidation and enhanced metabolic state.
Collectively, studies revealed the comprehensive nutraceutical significance of Curcumin, Resveratrol, Quercetin, and Kaempferol as anti-aging therapeutics and warrant future studies to exploit the full potential of these natural compounds.
衰老 是一种复杂的现象，涉及氧化应激、炎症和细胞损伤，随后会导致各种疾病，如心血管疾病、神经退行性疾病、糖尿病和癌症。沉默调节蛋白（SIRT）是影响人类衰老的主要分子因素之一。沉默调节蛋白是一类依赖烟酰胺腺嘌呤二核苷酸（NAD）的酶，可控制氧化应激反应、DNA损伤修复、炎症和代谢，所有这些都与衰老及与年龄相关的疾病有关。
本综述的目的是阐明SIRT在衰老过程中的潜在作用，以及通过姜黄素、白藜芦醇、槲皮素和山奈酚等选定植物化学物质对SIRT途径的调节作用。
研究确凿地表明，SIRT途径是延长人类健康寿命和解决与年龄相关病症的一个有前景的途径。姜黄素、白藜芦醇、槲皮素和山奈酚等植物化学物质通过其强大的抗氧化、抗炎和调节活性，显示出介导衰老效应的优异潜力。这些强大的生物活性化合物通过调节SIRT途径增强氧化应激反应、基因组完整性、神经保护和抗炎活性。此外，除了抗衰老作用外，每种化合物还具有其他治疗益处，包括神经疾病、癌症和代谢紊乱等，也进行了简要介绍。研究报告了令人信服的证据，表明姜黄素、白藜芦醇、槲皮素和山奈酚可有效调节SIRT表达/活性，从而提高细胞应激耐受性、减少氧化并增强代谢状态。
总体而言，研究揭示了姜黄素、白藜芦醇、槲皮素和山奈酚作为抗衰老疗法的全面营养保健意义，并值得未来开展研究以充分挖掘这些天然化合物的全部潜力。
