Department of Pharmacology and Therapeutics, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, M. Curie 9, 85-090 Bydgoszcz, Poland.
Department of Neurosurgery, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, M. Curie 9, 85-090 Bydgoszcz, Poland.
Nutrients. 2023 Aug 14;15(16):3578. doi: 10.3390/nu15163578.
Sirtuins are a family of proteins with enzymatic activity. There are seven mammalian sirtuins (SIRT1-SIRT7) that are found in different cellular compartments. They are a part of crucial cellular pathways and are regulated by many factors, such as chemicals, environmental stress, and phytochemicals. Several in vitro and in vivo studies have presented their involvement in anti-inflammatory, antioxidant, and antiapoptotic processes. Recent findings imply that phytochemicals such as resveratrol, curcumin, quercetin, fisetin, berberine, and kaempferol may regulate the activity of sirtuins. Resveratrol mainly activates SIRT1 and indirectly activates AMPK. Curcumin influences mainly SIRT1 and SIRT3, but its activity is broad, and many pathways in different cells are affected. Quercetin mainly modulates SIRT1, which triggers antioxidant and antiapoptotic responses. Fisetin, through SIRT1 regulation, modifies lipid metabolism and anti-inflammatory processes. Berberine has a wide spectrum of effects and a significant impact on SIRT1 signaling pathways. Finally, kaempferol triggers anti-inflammatory and antioxidant effects through SIRT1 induction. This review aims to summarize recent findings on the properties of phytochemicals in the modulation of sirtuin activity, with a particular focus on biochemical aspects.
Sirtuins 是具有酶活性的蛋白质家族。哺乳动物中有 7 种 sirtuins（SIRT1-SIRT7），它们存在于不同的细胞区室中。它们是关键细胞途径的一部分，并受许多因素的调节，如化学物质、环境压力和植物化学物质。一些体外和体内研究表明它们参与了抗炎、抗氧化和抗细胞凋亡过程。最近的研究结果表明，植物化学物质如白藜芦醇、姜黄素、槲皮素、漆黄素、小檗碱和山奈酚可能调节 sirtuins 的活性。白藜芦醇主要激活 SIRT1 并间接激活 AMPK。姜黄素主要影响 SIRT1 和 SIRT3，但它的活性广泛，不同细胞中的许多途径都受到影响。槲皮素主要调节 SIRT1，触发抗氧化和抗细胞凋亡反应。漆黄素通过 SIRT1 调节，调节脂代谢和抗炎过程。小檗碱具有广泛的作用，并对 SIRT1 信号通路产生重大影响。最后，山奈酚通过诱导 SIRT1 触发抗炎和抗氧化作用。本综述旨在总结植物化学物质在调节 sirtuin 活性方面的最新发现，特别关注生化方面。
