Philippoz Supitchaya, Adamopoulos Dionysios, Sologashvili Tornike, Steenberghe Mathieu van, Jolou Jalal, Huber Christoph, Cikirikcioglu Mustafa
Division of Cardiovascular Surgery, Department of Surgery, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.
Division of Cardiology, Department of Medical Specialties, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.
Aorta (Stamford). 2024 Dec;12(6):144-152. doi: 10.1055/s-0045-1809170. Epub 2025 May 13.
Acute Type A aortic dissection (AAAD) is a life-threatening condition, with surgery being the recommended treatment. However, there is ongoing debate regarding the optimal surgical procedure. This study aimed to evaluate the impact of implementing a standardized protocol, introduced in our institution in 2016, on AAAD management.A retrospective cohort study was conducted involving patients treated surgically for AAAD between 2010 and 2021 in our department. Patients were divided into two groups: those who underwent surgery before 2016 using operator-dependent techniques, and those who underwent surgery starting in 2016 using a standardized protocol.A total of 104 patients were included in this study. The mean age was 66.5 ± 11.4 years and 55.8% were male. Demographics and preoperative data were similar in both groups. Arterial and venous cannulation site of both groups were different ( < 0.001): femoral artery and vein cannulation for group 1 versus subclavian artery and central venous canulation for group 2. Alone ascending aorta replacement versus ascending aorta plus hemiarch replacement were the preferred techniques in groups 1 and 2, respectively ( < 0.001). Hypothermic circulatory arrest and cerebral perfusion were largely performed in group 2 compared with group 1 ( < 0.001). The total time of surgery, the cardiopulmonary bypass, and aortic cross-clamping times were longer in group 2 ( < 0.05). Both groups had similar rates of postoperative complications, except for late reoperation and aortic dilatation rates, which were less frequent in group 2 ( < 0.05).The implementation of a standardized institutional protocol can transform AAAD surgery from a "surgeon-tailored" to a " patient-tailored" approach. The use of a standardized protocol in our institution resulted in a significant reduction of aortic reoperation and aortic dilation rates, suggesting that the introduction of standardized protocols in low-volume centers may improve AAAD management.
急性A型主动脉夹层(AAAD)是一种危及生命的疾病,手术是推荐的治疗方法。然而,关于最佳手术方式的争论仍在继续。本研究旨在评估2016年在我们机构引入的标准化方案对AAAD管理的影响。
我们进行了一项回顾性队列研究,纳入了2010年至2021年在我们科室接受手术治疗的AAAD患者。患者分为两组:一组是2016年前采用依赖术者技术进行手术的患者,另一组是2016年起采用标准化方案进行手术的患者。
本研究共纳入104例患者。平均年龄为66.5±11.4岁,男性占55.8%。两组的人口统计学和术前数据相似。两组的动静脉插管部位不同(<0.001):第一组为股动脉和股静脉插管,第二组为锁骨下动脉和中心静脉插管。第一组和第二组分别首选单纯升主动脉置换术和升主动脉加半弓置换术(<0.001)。与第一组相比,第二组更多地进行了低温循环停搏和脑灌注(<0.001)。第二组的手术总时间、体外循环时间和主动脉阻断时间更长(<0.05)。除了再次手术和主动脉扩张率外,两组术后并发症发生率相似,第二组的再次手术和主动脉扩张率较低(<0.05)。
实施标准化的机构方案可以将AAAD手术从“以手术医生为导向”转变为“以患者为导向”的方法。我们机构使用标准化方案导致主动脉再次手术和主动脉扩张率显著降低,这表明在手术量较少的中心引入标准化方案可能会改善AAAD的管理。